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dc.contributor.authorSantana, Carlos José Correia-
dc.contributor.authorMagalhães, Ana Carolina Martins-
dc.contributor.authorPrías Márquez, César Augusto-
dc.contributor.authorFalico, Diego Alejandro-
dc.contributor.authorSantos Júnior, Agenor de Castro Moreira dos-
dc.contributor.authorLima, Beatriz Dolabela-
dc.contributor.authorRicart, Carlos André Ornelas-
dc.contributor.authorPilger, Denise Regina Bairros de-
dc.contributor.authorBonotto, Rafaela Milan-
dc.contributor.authorMoraes, Carolina Borsoi-
dc.contributor.authorFreitas Júnior, Lúcio Holanda de-
dc.contributor.authorMorales Álvares, Alice da Cunha-
dc.contributor.authorFreitas, Sônia Maria-
dc.contributor.authorLuz, Isabelle Souza-
dc.contributor.authorPires Júnior, Osmindo Rodrigues-
dc.contributor.authorFontes, Wagner-
dc.contributor.authorCastro, Mariana de Souza-
dc.date.accessioned2025-01-10T11:42:56Z-
dc.date.available2025-01-10T11:42:56Z-
dc.date.issued2020-05-20-
dc.identifier.citationSANTANA, Carlos José Correia et al. Biological properties of a novel multifunctional host defense peptide from the skin secretion of the chaco tree frog, Boana raniceps. Biomolecules, [S. l.], v. 10, n. 5, 790, 2020. DOI: https://doi.org/10.3390/biom10050790. Disponível em: https://www.mdpi.com/2218-273X/10/5/790. Acesso em: 10 jan. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/51306-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleBiological properties of a novel multifunctional host defense peptide from the skin secretion of the chaco tree frog, Boana ranicepspt_BR
dc.typeArtigopt_BR
dc.subject.keywordAnfíbiopt_BR
dc.subject.keywordSecreção cutâneapt_BR
dc.subject.keywordPeptídeospt_BR
dc.subject.keywordPeptídeos antimicrobianospt_BR
dc.subject.keywordNeutrófilospt_BR
dc.identifier.doihttps://doi.org/10.3390/biom10050790pt_BR
dc.description.abstract1In recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains. Thus, antimicrobial resistance has become a serious public health problem. Amphibian skin secretions are a rich source of host defense peptides, which generally are cationic and hydrophobic molecules, with a broad-spectrum of activity. In this study, one novel multifunctional defense peptide was isolated from the skin secretion of the Chaco tree frog, Boana raniceps. Figainin 2 (1FLGAILKIGHALAKTVLPMVTNAFKPKQ28) is cationic and hydrophobic, adopts an α-helical structure in 50% (v/v) trifluoroethanol (TFE), and is thermally stable. This peptide exhibited activity against Gram-negative and Gram-positive pathogenic bacteria arboviruses, T. cruzi epimastigotes; however, it did not show activity against yeasts. Figainin 2 also showed antiproliferative activity on cancer cells, is moderately active on human erythrocytes, and activates the oxidative burst in human neutrophils.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9781-3670pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0689-2770pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8722-5103pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9875-9407pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5140-8573pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Gene Biologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Gene Biologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiologypt_BR
dc.contributor.affiliationUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiologypt_BR
dc.contributor.affiliationUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiologypt_BR
dc.contributor.affiliationUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiologypt_BR
dc.contributor.affiliationUniversity of São Paulo, Institute of Biomedical Sciences, Department of Microbiologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Biophysicspt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Biophysicspt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Physiological Sciences, Laboratory of Toxinologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biology, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Animalpt_BR
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