| Élément Dublin Core | Valeur | Langue |
|---|
| dc.contributor.author | Ramos, Gracielle Vieira | - |
| dc.contributor.author | Sousa Neto, Ivo Vieira de | - |
| dc.contributor.author | Arruda, Alessandra Choqueta Toledo | - |
| dc.contributor.author | Marqueti, Rita de Cassia | - |
| dc.contributor.author | Vieira, Rodolfo P. | - |
| dc.contributor.author | Martins, Milton A. | - |
| dc.contributor.author | Salvini, Tânia F. | - |
| dc.contributor.author | Durigan, João Luiz Quaglioti | - |
| dc.date.accessioned | 2022-05-16T14:02:38Z | - |
| dc.date.available | 2022-05-16T14:02:38Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.citation | RAMOS, Gracielle Vieira et al. Moderate treadmill training induces limited effects on quadriceps muscle hypertrophy in mice exposed to cigarette smoke involving metalloproteinase 2. International Journal of Chronic Obstructive Pulmonary Disease, v. 17, p. 33-42, 2022. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/43716 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Dove Press | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Moderate treadmill training induces limited effects on quadriceps muscle hypertrophy in mice exposed to cigarette smoke involving metalloproteinase 2 | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Exercícios físicos | pt_BR |
| dc.subject.keyword | Doença pulmonar obstrutiva crônica | pt_BR |
| dc.subject.keyword | Metaloproteinases | pt_BR |
| dc.subject.keyword | Inflamação | pt_BR |
| dc.rights.license | © 2022 Vieira Ramos et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php) | pt_BR |
| dc.description.abstract1 | Background: Long-term cigarette smoke (CS) induces substantive extrapulmonary effects, including musculoskeletal system disorders. Exercise training seems to protect long-term smokers against fiber atrophy in the locomotor muscles. Nevertheless, the extracellular matrix (ECM) changes in response to aerobic training remain largely unknown. Thus, we investigated the effects of moderate treadmill training on aerobic performance, crosssectional area (CSA), fiber distribution, and metalloproteinase 2 (MMP-2) activity on quadriceps muscle in mice exposed to chronic CS. Methods: Male mice were randomized into four groups: control or smoke (6 per group) and exercise or exercise+smoke (5 per group). Animals were exposed to 12 commercially filtered
cigarettes per day (0.8 mg of nicotine, 10 mg of tar, and 10 mg of CO per cigarette). The CSA, fibers distribution, and MMP-2 activity by zymography were assessed after a period of treadmill training (50% of maximal exercise capacity for 60 min/day, 5 days/week) for 24 weeks. Results: The CS exposure did not change CSA compared to the control group (p>0.05), but
minor fibers in the frequency distribution (<1000 µm2 ) were observed. Long-term CS exposure attenuated CSA increases in exercise conditions (smoke+exercise vs exercise) while did not impair aerobic performance. Quadriceps CSA increased in mice nonsmoker submitted to aerobic training (p = 0.001). There was higher pro-MMP-2 activity in the smoke +exercise group when compared to the smoke group (p = 0.01). Regarding active MMP-2, the exercise showed higher values when compared to the control group (p = 0.001). Conclusion: Moderate treadmill training for 24 weeks in mice exposed to CS did not modify CSA, despite inducing higher pro-MMP-2 activity in the quadriceps muscle, suggesting limited effects on ECM remodeling. Our findings may contribute to new insights into molecular mechanisms for CS conditions. | pt_BR |
| dc.identifier.orcid | https://orcid.org/ 0000-0002-1479-5866 | pt_BR |
| dc.identifier.orcid | https://orcid.org/ 0000-0001-9126-3882 | pt_BR |
| dc.identifier.orcid | https://orcid.org/ 0000-0001-6379-1143 | pt_BR |
| Collection(s) : | Artigos publicados em periódicos e afins
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