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dc.contributor.authorFrazão, Stefânia de Oliveira-
dc.contributor.authorSousa, Herdson Renney de-
dc.contributor.authorSilva, Lenise Gonçalves da-
dc.contributor.authorFolha, Jéssica dos Santos-
dc.contributor.authorGorgonha, Kaio César de Melo-
dc.contributor.authorOliveira Júnior, Getúlio Pereira de-
dc.contributor.authorFelipe, Maria Sueli Soares-
dc.contributor.authorPereira, Ildinete Silva-
dc.contributor.authorCasadevall, Arturo-
dc.contributor.authorNicola, André Moraes-
dc.contributor.authorAndrade, Patrícia Albuquerque de-
dc.date.accessioned2021-01-20T17:02:37Z-
dc.date.available2021-01-20T17:02:37Z-
dc.date.issued2020-09-08-
dc.identifier.citationFRAZÃO, Stefânia de Oliveira et al. Laccase affects the rate of Cryptococcus neoformans nonlytic exocytosis from macrophages. mBio, v. 11, n. 5, e02085-20, 2020. DOI: https://doi.org/10.1128/mBio.02085-20. Disponível em: https://mbio.asm.org/content/11/5/e02085-20. Acesso em: 20 jan. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/39934-
dc.language.isoInglêspt_BR
dc.publisherAmerican Society for Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleLaccase affects the rate of Cryptococcus neoformans nonlytic exocytosis from macrophagespt_BR
dc.typeArtigopt_BR
dc.subject.keywordCryptococcus neoformanspt_BR
dc.subject.keywordLeveduraspt_BR
dc.subject.keywordEnzimas de fungospt_BR
dc.subject.keywordMacrófagospt_BR
dc.subject.keywordExocitose não-líticapt_BR
dc.rights.licenseCopyright © 2020 Frazão et al. This is an openaccess article distributed under the terms of the Creative Commons Attribution 4.0 International license.pt_BR
dc.identifier.doihttps://doi.org/10.1128/mBio.02085-20pt_BR
dc.description.abstract1Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages and ameboid predators. Despite a great amount of research dedicated to unraveling this process, there are still many questions about its regulation and its final benefits for host or fungal cells. During a study to characterize the virulence attributes of Brazilian clinical isolates of C. neoformans, we observed great variability in their rates of nonlytic exocytosis and noted a correlation between this process and fungal melanin production/laccase activity. Flow cytometry experiments using melanized cells, nonmelanized cells, and lac1Δ mutants revealed that laccase has a role in the process of nonlytic exocytosis that seems to be independent of melanin production. These results identify a role for laccase in virulence, independent of its role in pigment production, that represents a new variable in the regulation of nonlytic exocytosis.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0067-1969pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7606-0972pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9861-1042pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6737-6705pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6940-401Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4347-6853pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1403-9363pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9402-9167pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8656-5835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8160-7784pt_BR
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