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dc.contributor.authorMcCullough, Peter A.-
dc.contributor.authorAlexander, Paul E.-
dc.contributor.authorArmstrong, Robin-
dc.contributor.authorArvinte, Cristian-
dc.contributor.authorBain, Alan F.-
dc.contributor.authorBartlett, Richard P.-
dc.contributor.authorBerkowitz, Robert L.-
dc.contributor.authorBerry, Andrew C.-
dc.contributor.authorBorody, Thomas J.-
dc.contributor.authorBrewer, Joseph H.-
dc.contributor.authorBrufsky, Adam M.-
dc.contributor.authorClarke, Teryn-
dc.contributor.authorDerwand, Roland-
dc.contributor.authorEck, Alieta-
dc.contributor.authorEck, John-
dc.contributor.authorEisner, Richard A.-
dc.contributor.authorFareed, George C.-
dc.contributor.authorFarella, Angelina-
dc.contributor.authorFonseca, Silvia N. S.-
dc.contributor.authorGeyer Jr., Charles E.-
dc.contributor.authorGonnering, Russell S.-
dc.contributor.authorGraves, Karladine E.-
dc.contributor.authorGross, Kenneth B. V.-
dc.contributor.authorHazan, Sabine-
dc.contributor.authorHeld, Kristin S.-
dc.contributor.authorHight, H. Thomas-
dc.contributor.authorImmanuel, Stella-
dc.contributor.authorJacobs, Michael M.-
dc.contributor.authorLadapo, Joseph A.-
dc.contributor.authorLee, Lionel H.-
dc.contributor.authorLittell, John-
dc.contributor.authorLozano, Ivette-
dc.contributor.authorMangat, Harpal S.-
dc.contributor.authorMcKinnon, John E.-
dc.contributor.authorMerritt, Lee D.-
dc.contributor.authorOrient, Jane M.-
dc.contributor.authorOskoui, Ramin-
dc.contributor.authorPompan, Donald C.-
dc.contributor.authorProcter, Brian C.-
dc.contributor.authorProdromos, Chad-
dc.contributor.authorRajter, Juliana Cepelowicz-
dc.contributor.authorRajter, Jean-Jacques-
dc.contributor.authorRam, C. Venkata S.-
dc.contributor.authorRios, Salete da Silva-
dc.contributor.authorRisch, Harvey A.-
dc.contributor.authorRobb, Michael J. A.-
dc.contributor.authorRutherford, Molly-
dc.contributor.authorScholz, Martin-
dc.contributor.authorSingleton, Marilyn M.-
dc.contributor.authorTumlin, James A.-
dc.contributor.authorTyson, Brian M.-
dc.contributor.authorUrso, Richard G.-
dc.contributor.authorVictory, Kelly-
dc.contributor.authorVliet, Elizabeth Lee-
dc.contributor.authorWax, Craig M.-
dc.contributor.authorWolkoff, Alexandre G.-
dc.contributor.authorWooll, Vicki-
dc.contributor.authorZelenko, Vladimir-
dc.date.accessioned2021-01-11T18:41:52Z-
dc.date.available2021-01-11T18:41:52Z-
dc.date.issued2020-12-30-
dc.identifier.citationMCCULLOUGH, Peter A. et al. Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Reviews in Cardiovascular Medicine, v. 21, n. 4, p. 517-530, 2020. DOI: 10.31083/j.rcm.2020.04.264. Disponível em: https://rcm.imrpress.com/article/2020/2153-8174/RCM2020264.shtml. Acesso em: 11 jan. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/39875-
dc.language.isoInglêspt_BR
dc.publisherIMR Presspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMultifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19)pt_BR
dc.typeArtigopt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordCovid-19pt_BR
dc.subject.keywordHospitalizaçãopt_BR
dc.subject.keywordMortalidadept_BR
dc.subject.keywordTratamentopt_BR
dc.subject.keywordMedicamentospt_BR
dc.rights.licenseThis is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).pt_BR
dc.identifier.doi10.31083/j.rcm.2020.04.264pt_BR
dc.description.abstract1The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis warrants early interventions to address all components of the devastating illness. In countries where therapeutic nihilism is prevalent, patients endure escalating symptoms and without early treatment can succumb to delayed in-hospital care and death. Prompt early initiation of sequenced multidrug therapy (SMDT) is a widely and currently available solution to stem the tide of hospitalizations and death. A multipronged therapeutic approach includes 1) adjuvant nutraceuticals, 2) combination intracellular anti-infective therapy, 3) inhaled/oral corticosteroids, 4) antiplatelet agents/anticoagulants, 5) supportive care including supplemental oxygen, monitoring, and telemedicine. Randomized trials of individual, novel oral therapies have not delivered tools for physicians to combat the pandemic in practice. No single therapeutic option thus far has been entirely effective and therefore a combination is required at this time. An urgent immediate pivot from single drug to SMDT regimens should be employed as a critical strategy to deal with the large numbers of acute COVID-19 patients with the aim of reducing the intensity and duration of symptoms and avoiding hospitalization and death.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0997-6355pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8425-438Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8952-6559pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8080-7960pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2379-5702pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5228-7512pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1846-6354pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3916-4021pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4378-3458pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3520-281Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1162-6263pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5337-3941pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3019-4139pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2373-2576pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8681-8214pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4347-8621pt_BR
dc.description.unidadeFaculdade de Medicina (FM)-
Aparece en las colecciones: Artigos publicados em periódicos e afins
UnB - Covid-19

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