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dc.contributor.authorStefani, Chiara-
dc.contributor.authorSangalli, Antonella-
dc.contributor.authorLocatelli, Elena-
dc.contributor.authorFederico, Tania-
dc.contributor.authorMalerba, Giovanni-
dc.contributor.authorRomanelli, Maria Grazia-
dc.contributor.authorArgañaraz, Gustavo Adolfo-
dc.contributor.authorSilva, Bosco Christiano Maciel da-
dc.contributor.authorSilva, Alberto Jose Duarte da-
dc.contributor.authorCasseb, Jorge-
dc.contributor.authorArgañaraz, Enrique Roberto-
dc.contributor.authorRuggiero, Alessandra-
dc.contributor.authorZipeto, Donato-
dc.date.accessioned2025-02-25T13:05:27Z-
dc.date.available2025-02-25T13:05:27Z-
dc.date.issued2022-11-27-
dc.identifier.citationSTEFANI, Chiara et al. Increased prevalence of unstable HLA-C variants in HIV-1 rapid-progressor patients. International Journal Molecular Sciences, [S. l.], v. 23, n. 23, 14852, 2022. DOI: https://doi.org/10.3390/ijms232314852. Disponível em: https://www.mdpi.com/1422-0067/23/23/14852. Acesso em: 25 fev. 2025.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/51722-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleIncreased prevalence of unstable HLA-C variants in HIV-1 rapid-progressor patientspt_BR
dc.typeArtigopt_BR
dc.subject.keywordAIDS (Doença)pt_BR
dc.subject.keywordHIV-1pt_BR
dc.subject.keywordAntígenospt_BR
dc.rights.licenseThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms232314852pt_BR
dc.description.abstract1HIV-1 infection in the absence of treatment results in progression toward AIDS. Host genetic factors play a role in HIV-1 pathogenesis, but complete knowledge is not yet available. Since less-expressed HLA-C variants are associated with poor HIV-1 control and unstable HLA-C variants are associated with higher HIV-1 infectivity, we investigated whether there was a correlation between the different stages of HIV-1 progression and the presence of specific HLA-C allotypes. HLA-C genotyping was performed using allele-specific PCR by analyzing a treatment-naïve cohort of 96 HIV-1-infected patients from multicentric cohorts in the USA, Canada, and Brazil. HIV-1-positive subjects were classified according to their different disease progression status as progressors (Ps, n = 48), long-term non-progressors (LTNPs, n = 37), and elite controllers (ECs, n = 11). HLA-C variants were classified as stable or unstable according to their binding stability to β2-microglobulin/peptide complex. Our results showed a significant correlation between rapid progression to AIDS and the presence of two or one unstable HLA-C variants (p-value: 0.0078, p-value: 0.0143, respectively). These findings strongly suggest a link between unstable HLA-C variants both at genotype and at allele levels and rapid progression to AIDS. This work provides further insights into the impact of host genetic factors on AIDS progression.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8705-8560pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7360-1195pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3883-7178pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4553-2559pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4359-7594pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2168-4144pt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Lab of Molecular NeuroVirologypt_BR
dc.contributor.affiliationUniversity of São Paulo, Faculdade de Medicina FMUSP, Medical Investigation Laboratory Unit 56 (LIM/56)pt_BR
dc.contributor.affiliationUniversity of São Paulo, Faculdade de Medicina FMUSP, Medical Investigation Laboratory Unit 56 (LIM/56)pt_BR
dc.contributor.affiliationUniversity of São Paulo, Institute of Tropical Medicine, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Science, Lab of Molecular NeuroVirologypt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.contributor.affiliationUniversity of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Geneticspt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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