Título:	SynBio in 3D : the first synthetic genetic circuit as a 3D printed STEM educational resource
Autor(es):	Boll, Heloísa Oss Leitão, Matheus de Castro Garay, Aisel Valle Batista, Ana Carolina Campos Resende, Sophia Garcia de Silva, Leonardo Ferreira da Reis, Viviane Castelo Branco Vieira, Emerson Monteiro Coelho, Cíntia Marques
Afiliação do autor:	University of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Synthetic Biology University of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Synthetic Biology University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Molecular Biophysics University of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Synthetic Biology University of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Synthetic Biology University of Brasília, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Molecular Biology University of Brasília, Institute of Biological Sciences, Department of Ecology, Laboratory of Vertebrate Ecology University of Brasília, Institute of Biological Sciences, Department of Genetics and Morphology, Laboratory of Synthetic Biology
Assunto:	Biologia sintética Circuitos genéticos Impressão 3D Recursos educacionais Biotecnologia
Data de publicação:	17-Mar-2023
Editora:	Frontiers
Referência:	BOLL, Heloísa Oss et al. SynBio in 3D: The first synthetic genetic circuit as a 3D printed STEM educational resource. Frontiers in Education, v. 8, 1110464, 2023. DOI: https://doi.org/10.3389/feduc.2023.1110464. Disponível em: https://www.frontiersin.org/journals/education/articles/10.3389/feduc.2023.1110464/full. Acesso em: 17 fev. 2025.
Abstract:	Synthetic biology is a new area of science that operates at the intersection of engineering and biology and aims to design and synthesize living organisms and systems to perform new or improved functions. Despite the important role it plays in resolving global issues, instructing synthetic biology can be challenged by a limited availability of specific educational materials and techniques for explaining complex molecular mechanisms. On the other hand, digital fabrication tools, which allow the creation of 3D objects, are increasingly used for educational purposes, and several computational structures of molecular components commonly used in synthetic biology processes are deposited in open databases. Therefore, we hypothesized that the use of computer-assisted design (CAD) and 3D printing to create biomolecular structural models through hands-on interaction, followed by reflective observation, critical and analytical thinking, could enhance students’ learning in synthetic biology. In this sense, the present work describes the design, 3D printing process, and evaluation in classrooms of the molecular models of the first synthetic biological circuit, the genetic toggle switch. The 3D printed molecular structures can be freely downloaded and used by teachers to facilitate the training of STEM students in synthetic biology. Most importantly, the results demonstrated that our resource showed a significant positive impact (p < 0.05) on students’ learning process, indicating that the proposed method helped them better understand the genetic toggle switch.
Unidade Acadêmica:	Instituto de Ciências Biológicas (IB) Departamento de Genética e Morfologia (IB GEM) Departamento de Biologia Celular (IB CEL) Departamento de Ecologia (IB ECL)
Programa de pós-graduação:	Programa de Pós-Graduação em Ciências Biológicas Programa de Pós-Graduação em Biologia Molecular
Licença:	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
DOI:	https://doi.org/10.3389/feduc.2023.1110464
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