Título:	Sorghum phytonutrients and their health benefits : a systematic review from cell to clinical trials
Autor(es):	Oliveira, Lívia de Lacerda de Figueiredo, Lúcio Flávio de Alencar
Afiliação do autor:	University of Brasília, Faculty of Health Sciences, Department of Nutrition University of Brasília, Institute of Biology, Department of Botany
Assunto:	Anti-inflamatórios Antioxidantes Doenças crônicas Sorgo
Data de publicação:	22-Mar-2024
Editora:	Wiley
Referência:	OLIVEIRA, Lívia de Lacerda de; FIGUEREDO, Lúcio Flávio de Alencar. Sorghum phytonutrients and their health benefits: a systematic review from cell to clinical trials. Journal Food Science, 2024. DOI: https://doi.org/10.1111/1750-3841.17011.
Abstract:	Sorghum is key for global food security due to its genetic variability, resilience, and rich phytonutrient content, which are linked to numerous health bene fits. A systematic review assessed the health effects of sorghum by analyzing cell (n = 22), animal (n = 20), and human (n = 7) studies across antioxidant, anti-inflammatory, obesity, cancer, cardiovascular, and diabetes outcomes. This review, involving 42 papers and 177 researchers from 12 countries, collected data from sorghum accessions (acc) and significant effects. Studies used 68 identi fied and 8 unidentified sorghums, 57% red (n = 20), brown (n = 5), and black (n = 17) pericarp colors, and evaluated whole (n = 31), brans (n = 11), and decorti cated grains (n = 2). Colored sorghum, richer in phenolic compounds, especially 3-deoxyanthocyanins and tannins, inhibited cancer cell activities, including proliferation, tumor growth, and ROS activity, and promoted cell cycle arrest and apoptosis. Sorghum elevated HO1 and eNOS expression for cardiovascu lar, health-reduced platelet aggregation, and modulated platelet microparticles. They also suppressed inflammation markers and decreased lipid accumulation. Animal studies indicated sorghum’s potential across antioxidant capacity, can cer and inflammation mitigation, and lipid and glucose metabolism. Translating these findings to human scenarios requires caution, especially considering cell studies do not fully represent polyphenol metabolism. Human studies provided mixed results, indicating antioxidant and potential anti-inflammatory benefits and nuanced effects on glucose and lipid metabolism. The main risks of bias highlighted challenges in quantifying phytonutrients, identifying sorghum acc features, and lack of assessors blinding. Nonetheless, sorghum emerges as a promising functional food for countering chronic diseases in Western diets.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Nutrição (FS NUT) Instituto de Ciências Biológicas (IB) Departamento de Botânica (IB BOT)
DOI:	https://doi.org/10.1111/1750-3841.17011
Versão da editora:	https://ift.onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.17011
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