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dc.contributor.authorSilvestre, Fernanda Altino-
dc.contributor.authorSantos, Carolina-
dc.contributor.authorSilva, Vitória R. P.-
dc.contributor.authorOmbredane, Alicia Simalie-
dc.contributor.authorPinheiro, Willie Oliveira-
dc.contributor.authorAndrade, Laise Rodrigues de-
dc.contributor.authorGarcia, Mônica P.-
dc.contributor.authorPacheco, Thyago-
dc.contributor.authorJoanitti, Graziella Anselmo-
dc.contributor.authorLuz, Glécia Virgolino da Silva-
dc.contributor.authorCarneiro, Marcella Lemos Brettas-
dc.date.accessioned2024-09-09T10:31:29Z-
dc.date.available2024-09-09T10:31:29Z-
dc.date.issued2023-06-29-
dc.identifier.citationSILVESTRE, Fernanda et al. Pharmacokinetics of curcumin delivered by nanoparticles and the relationship with antitumor efficacy: a systematic review. Pharmaceuticals, [S. l.], v. 16, n. 7, 943, 2023. DOI: https://doi.org/10.3390/ph16070943. Disponível em: https://www.mdpi.com/1424-8247/16/7/943. Acesso em: 05 set. 2024.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/50310-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePharmacokinetics of curcumin delivered by nanoparticles and the relationship with antitumor efficacy : a systematic reviewpt_BR
dc.typeArtigopt_BR
dc.subject.keywordCurcuminapt_BR
dc.subject.keywordFarmacocinéticapt_BR
dc.subject.keywordNanopartículaspt_BR
dc.subject.keywordCâncerpt_BR
dc.rights.licenseCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/ph16070943pt_BR
dc.description.abstract1Curcumin is a polyphenolic compound, derived from Curcuma longa, and it has sev- eral pharmacological effects such as antioxidant, anti-inflammatory, and antitumor. Although it is a pleiotropic molecule, curcumin’s free form, which is lipophilic, has low bioavailability and is rapidly metabolized, limiting its clinical use. With the advances in techniques for loading curcumin into nanostructures, it is possible to improve its bioavailability and extend its applications. In this review, we gather evidence about the comparison of the pharmacokinetics (biodistribution and bioavailability) between free curcumin (Cur) and nanostructured curcumin (Cur-NPs) and their re- spective relationships with antitumor efficacy. The search was performed in the following databases: Cochrane, LILACS, Embase, MEDLINE/Pubmed, Clinical Trials, BSV regional portal, ScienceDirect, Scopus, and Web of Science. The selected studies were based on studies that used High-Performance Liquid Chromatography (HPLC) as the pharmacokinetics evaluation method. Of the 345 studies initially pooled, 11 met the inclusion criteria and all included studies classified as high quality. In this search, a variety of nanoparticles used to deliver curcumin (polymeric, copolymeric, nanocrystals, nanovesicles, and nanosuspension) were found. Most Cur-NPs presented negative Zeta potential ranging from −25 mV to 12.7 mV, polydispersion index (PDI) ranging from 0.06 to 0.283, and hy- drodynamic diameter ranging from 30.47 to 550.1 nm. Selected studies adopted mainly oral and intravenous administrations. In the pharmacokinetics analysis, samples of plasma, liver, tumor, lung, brain, kidney, and spleen were evaluated. The administration of curcumin, in nanoparticle systems, resulted in a higher level of curcumin in tumors compared to free curcumin, leading to an improved antitumor effect. Thus, the use of nanoparticles can be a promising alternative for curcumin delivery since this improves its bioavailability.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8361-4854pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5385-6174pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6165-0969pt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Gama, Post-Graduate Program in Biomedical Engineeringpt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Department of Nutritionpt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândia, Post-Graduate Program in Sciences and Technologies in Healthpt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Animal Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilândia, Post-Graduate Program in Sciences and Technologies in Healthpt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Gama, Post-Graduate Program in Biomedical Engineeringpt_BR
dc.contributor.affiliationUniversity of Brasilia, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduate Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Gama, Post-Graduate Program in Biomedical Engineeringpt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Nutrição (FS NUT)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeFaculdade UnB Gama (FGA)pt_BR
dc.description.unidadeFaculdade UnB Planaltina (FUP)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Nanociência e Nanobiotecnologiapt_BR
dc.description.ppgPrograma Pós-Graduação em Engenharia Biomédicapt_BR
dc.description.ppgPrograma Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
dc.description.ppgPrograma de Pós-Graduação em Biologia Animalpt_BR
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