| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Fratelli, Caroline Ferreira | - |
| dc.contributor.author | Siqueira, Jhon Willatan | - |
| dc.contributor.author | Gontijo, Bruna Rodrigues | - |
| dc.contributor.author | Santos, Maurício de Lima | - |
| dc.contributor.author | Silva, Calliandra Maria de Souza | - |
| dc.contributor.author | Silva, Izabel Cristina Rodrigues da | - |
| dc.date.accessioned | 2024-07-05T15:16:05Z | - |
| dc.date.available | 2024-07-05T15:16:05Z | - |
| dc.date.issued | 2021-11-10 | - |
| dc.identifier.citation | FRATELLI, Caroline Ferreira et al. BDNF genetic variant and its genotypic fluctuation in major depressive disorder. Behavioural Neurology, v. 2021, Article ID 7117613, 16 p., 2021. DOI: https://doi.org/10.1155/2021/7117613. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2021/7117613. Acesso em: 05 jul. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/48568 | - |
| dc.language.iso | por | pt_BR |
| dc.publisher | Wiley Open Access | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | BDNF genetic variant and its genotypic fluctuation in major depressive disorder | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Polimorfismo (Genética) | - |
| dc.subject.keyword | Depressão mental | - |
| dc.rights.license | © 2021 Caroline Ferreira Fratelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1155/2021/7117613 | pt_BR |
| dc.description.abstract1 | Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients. | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilândia, Health Sciences and Technologies Program | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilândia | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilândia, Health Sciences and Technologies Program | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilândia | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilândia | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Ceilândia | pt_BR |
| dc.contributor.orcid | https://orcid.org/0000-0002-6836-3583 | - |
| dc.description.unidade | Faculdade UnB Ceilândia (FCE) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Ciências e Tecnologias em Saúde | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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