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dc.contributor.authorDuarte, Isabella de Araújo Esteves-
dc.contributor.authorMilenkovic, Dragan-
dc.contributor.authorBorges, Tatiana Karla dos Santos Borges-
dc.contributor.authorRosa, Artur Jordão de Magalhães-
dc.contributor.authorMorand, Cristine-
dc.contributor.authorOliveira, Livia de Lacerda-
dc.contributor.authorCosta, Ana Maria-
dc.date.accessioned2024-03-26T13:13:13Z-
dc.date.available2024-03-26T13:13:13Z-
dc.date.issued2020-04-16-
dc.identifier.citationDUARTE, Isabella de Araújo Esteves et al. Acute effects of the consumption of passiflora setacea juice on metabolic risk factors and gene expression profile in humans. Nutrients, [S.l.], v. 12, n. 4, 16 abril 2020. Disponível em: https://www.mdpi.com/2072-6643/12/4/1104. Acesso em: 19 mar 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48038-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAcute effects of the consumption of passiflora setacea juice on metabolic risk factors and gene expression profile in humanspt_BR
dc.typeArtigopt_BR
dc.subject.keywordAtividade anti-inflamatóriapt_BR
dc.subject.keywordMaracujá - aspectos genéticospt_BR
dc.rights.license©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/nu12041104pt_BR
dc.description.abstract1Background: Passiflora setacea (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans. Methods: Overweight male volunteers (n = 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2). Results: Insulin and homeostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine–cytokine receptor. Conclusion: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6276-3060pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6353-0912pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7015-9207pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4456-7802pt_BR
dc.contributor.affiliationUniversidade de Brasília, Campus Universitário Darcy Ribeiro, College of Health Sciences, Postgraduate Program in Human Nutritionpt_BR
dc.contributor.affiliationUNH, INRAE, Université Clermont Auvergne, Unité de Nutrition Humainept_BR
dc.contributor.affiliationUniversity of California Davis, School of Medicine, Division of Cardiovascular Medicine, Department of Internal Medicine.pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Laboratory of Cellular Immunologypt_BR
dc.contributor.affiliationEmbrapa Cerrados, Laboratory of Food Sciencept_BR
dc.contributor.affiliationUNH, INRAE, Université Clermont Auvergne, Unité de Nutrition Humainept_BR
dc.contributor.affiliationUniversidade de Brasília, Campus Universitário Darcy Ribeiro, College of Health Sciences, Postgraduate Program in Human Nutritionpt_BR
dc.contributor.affiliationEmbrapa Cerrados, Laboratory of Food Sciencept_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Nutrição Humanapt_BR
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