| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Duarte, Isabella de Araújo Esteves | - |
| dc.contributor.author | Milenkovic, Dragan | - |
| dc.contributor.author | Borges, Tatiana Karla dos Santos Borges | - |
| dc.contributor.author | Rosa, Artur Jordão de Magalhães | - |
| dc.contributor.author | Morand, Cristine | - |
| dc.contributor.author | Oliveira, Livia de Lacerda | - |
| dc.contributor.author | Costa, Ana Maria | - |
| dc.date.accessioned | 2024-03-26T13:13:13Z | - |
| dc.date.available | 2024-03-26T13:13:13Z | - |
| dc.date.issued | 2020-04-16 | - |
| dc.identifier.citation | DUARTE, Isabella de Araújo Esteves et al. Acute effects of the consumption of passiflora setacea juice on metabolic risk factors and gene expression profile in humans. Nutrients, [S.l.], v. 12, n. 4, 16 abril 2020. Disponível em: https://www.mdpi.com/2072-6643/12/4/1104. Acesso em: 19 mar 2024. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/48038 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Acute effects of the consumption of passiflora setacea juice on metabolic risk factors and gene expression profile in humans | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Atividade anti-inflamatória | pt_BR |
| dc.subject.keyword | Maracujá - aspectos genéticos | pt_BR |
| dc.rights.license | ©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/nu12041104 | pt_BR |
| dc.description.abstract1 | Background: Passiflora setacea (PS) is a passionfruit variety of the Brazilian savannah and is a rich source of plant food bioactives with potential anti-inflammatory activity. This study aimed to investigate the effect of an acute intake of PS juice upon inflammation, metabolic parameters, and gene expression on circulating immune cells in humans. Methods: Overweight male volunteers (n = 12) were enrolled in two double-blind placebo-controlled studies. Blood samples were collected from fasting volunteers 3 h after the consumption of 250 mL of PS juice or placebo (PB). Metabolic parameters (insulin, glucose, total cholesterol, high-density lipoprotein (LDL), high-density lipoprotein (HDL), and total triglycerides) and circulating cytokines were evaluated (study 1). Peripheral blood mononuclear cell (PBMC) from the same subjects were isolated and RNA was extracted for transcriptomic analyses using microarrays (study 2). Results: Insulin and homeostatic model assessment for insulin resistance (HOMA-IR) levels decreased statistically after the PS juice intake, whereas HDL level increased significantly. Interleukin (IL)-17A level increased after placebo consumption, whereas its level remained unchanged after PS juice consumption. Nutrigenomic analyses revealed 1327 differentially expressed genes after PS consumption, with modulated genes involved in processes such as inflammation, cell adhesion, or cytokine–cytokine receptor. Conclusion: Taken together, these clinical results support the hypothesis that PS consumption may help the prevention of cardiometabolic diseases. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-6276-3060 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-6353-0912 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-7015-9207 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-4456-7802 | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Campus Universitário Darcy Ribeiro, College of Health Sciences, Postgraduate Program in Human Nutrition | pt_BR |
| dc.contributor.affiliation | UNH, INRAE, Université Clermont Auvergne, Unité de Nutrition Humaine | pt_BR |
| dc.contributor.affiliation | University of California Davis, School of Medicine, Division of Cardiovascular Medicine, Department of Internal Medicine. | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Faculty of Medicine, Laboratory of Cellular Immunology | pt_BR |
| dc.contributor.affiliation | Embrapa Cerrados, Laboratory of Food Science | pt_BR |
| dc.contributor.affiliation | UNH, INRAE, Université Clermont Auvergne, Unité de Nutrition Humaine | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Campus Universitário Darcy Ribeiro, College of Health Sciences, Postgraduate Program in Human Nutrition | pt_BR |
| dc.contributor.affiliation | Embrapa Cerrados, Laboratory of Food Science | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Nutrição Humana | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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