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Título: Chemical and biological evaluation of amazonian medicinal plant vouacapoua americana aubl
Autor(es): Çiçek, Serhat Sezai
Barbosa, Anna Laís Pfeifer
Wenzel-Storjohann, Arlette
Segovia, Jorge Federico Orellana
Bezerra, Roberto Messias
Sönnichsen, Frank
Zidorn, Christian
Kanzaki, Isamu
Tasdemir, Deniz
ORCID: https://orcid.org/0000-0002-3038-8523
https://orcid.org/0000-0002-4539-3755
https://orcid.org/0000-0001-8956-9874
https://orcid.org/0000-0002-7841-6271
Afiliação do autor: Kiel University, Department of Pharmaceutical Biology
Kiel University, Department of Pharmaceutical Biology
GEOMAR Helmholtz Centre for Ocean Research Kiel, GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry
Brazilian Agricultural Research Corporation, Ecoregional Research Unit
Federal University of Amapá, Laboratory of Bioprospection and Atomic Absorption
Kiel University, Otto Diels Institute for Organic Chemistry
Kiel University, Department of Pharmaceutical Biology
University of Brasilia, Darcy Ribeiro Campus, Laboratory of Bioprospection
GEOMAR Helmholtz Centre for Ocean Research Kiel, GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry
Kiel University, Faculty of Mathematics and Natural Sciences
Assunto: Antimicrobiano
Acapu
Plantas medicinais
Data de publicação: 25-Dez-2022
Editora: MDPI
Referência: ÇIÇEK, Serhat Seai et al. Chemical and biological evaluation of amazonian medicinal plant vouacapoua americana aubl. Plants, [S.l.], v. 12, n. 99, 25 dez 2022. Disponível em: https://doi.org/10.3390/plants12010099. Acesso em: 20 mar 2024.
Abstract: Vouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures for further drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.
Unidade Acadêmica: Faculdade de Ciências da Saúde (FS)
Departamento de Farmácia (FS FAR)
Licença: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
DOI: https://doi.org/10.3390/plants12010099
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