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dc.contributor.authorPinheiro, Andréia Camargo-
dc.contributor.authorOmbredane, Alicia Simalie-
dc.contributor.authorPinheiro, Willie Oliveira-
dc.contributor.authorAndrade, Laise R.-
dc.contributor.authorSilva, Vitória R. P.-
dc.contributor.authorFelice, Gisela J.-
dc.contributor.authorAlves, Débora S.-
dc.contributor.authorAlbernaz, Aryanne F.-
dc.contributor.authorSilveira, Ariene Pandolfo-
dc.contributor.authorLima, Milena Campelo Freitas-
dc.contributor.authorVeiga-Junior, Valdir Florencio-
dc.contributor.authorGomes, Thamis F. S.-
dc.contributor.authorDamasceno, Emanuel Adelino Medeiros-
dc.contributor.authorSouza, Fabiane Hiratsuka Veiga-
dc.contributor.authorSouza, Paulo Eduardo Narcizo de-
dc.contributor.authorBáo, Sônia Nair-
dc.contributor.authorDuarte, Eliza Carla Barroso-
dc.contributor.authorCarneiro, Marcella Lemos Brettas-
dc.contributor.authorAzevedo, Ricardo Bentes-
dc.contributor.authorFunez, Mani Indiana-
dc.contributor.authorJoanitti, Graziella Anselmo-
dc.date.accessioned2024-02-08T12:24:07Z-
dc.date.available2024-02-08T12:24:07Z-
dc.date.issued2022-11-30-
dc.identifier.citationPINHEIRO, Andréia C. et al. Evaluation of biocompatibility, anti-inflammatory, and antinociceptive activities of pequi oil-based nanoemulsion in in vitro and in vivo models. Nanomaterials, [S. l.], v. 12, n. 23, 4260, 2022. DOI: https://doi.org/10.3390/nano12234260. Disponível em: https://www.mdpi.com/2079-4991/12/23/4260. Acesso em: 08 fev. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47705-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEvaluation of biocompatibility, anti-inflammatory, and antinociceptive activities of pequi oil-based nanoemulsion in in vitro and in vivo modelspt_BR
dc.typeArtigopt_BR
dc.subject.keywordNanoemulsãopt_BR
dc.subject.keywordÓleo de pequipt_BR
dc.subject.keywordAnti-inflamatóriospt_BR
dc.subject.keywordNanobiotecnologiapt_BR
dc.rights.licenseCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/nano12234260pt_BR
dc.description.abstract1Pequi oil (Caryocar brasiliense) contains bioactive compounds capable of modulating the inflammatory process; however, its hydrophobic characteristic limits its therapeutic use. The encapsulation of pequi oil in nanoemulsions can improve its biodistribution and promote its immunomodulatory effects. Thus, the objective of the present study was to formulate pequi oil-based nanoemulsions (PeNE) to evaluate their biocompatibility, anti-inflammatory, and antinociceptive effects in in vitro (macrophages—J774.16) and in vivo (Rattus novergicus) models. PeNE were biocompatible, showed no cytotoxic and genotoxic effects and no changes in body weight, biochemistry, or histology of treated animals at all concentrations tested (90–360 µg/mL for 24 h, in vitro; 100–400 mg/kg p.o. 15 days, in vivo). It was possible to observe antinociceptive effects in a dose-dependent manner in the animals treated with PeNE, with a reduction of 27 and 40% in the doses of 100 and 400 mg/kg of PeNE, respectively (p < 0.05); however, the treatment with PeNE did not induce edema reduction in animals with carrageenan-induced edema. Thus, the promising results of this study point to the use of free and nanostructured pequi oil as a possible future approach to a preventive/therapeutic complementary treatment alongside existing conventional therapies for analgesia.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1365-7602pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9873-3098pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2137-9588pt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationMilitary Institute of Engineering, Chemistry Section, Rio de Janeiropt_BR
dc.contributor.affiliationMilitary Institute of Engineering, Chemistry Section, Rio de Janeiropt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationRegional Hospital of Taguatinga, Health Department, Nucleus of Cytopathology and Anatomic Pathologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Protein Chemistry and Biochemistrypt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ceilândia, Faculdade de Ciências Farmacêuticaspt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Physics, Laboratory of Electron Paramagnetic Resonancept_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Department of Cell Biology, Laboratory of Microscopy and Microanalysispt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Department of Pathologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Gama, Post-Graduation Program in Biomedical Engineeringpt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Ceilândia, Nursing Coursept_BR
dc.contributor.affiliationUniversity of Brasilia, Ceilândia Sul, Laboratory of Bioactive Compounds and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Post-Graduation Program in Nanoscience and Nanobiotechnologypt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Ceilândia, Postgraduate Program in Health Sciences and Technologiespt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.unidadeCurso de Farmácia (FCE-FAR)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeFaculdade UnB Gama (FGA)pt_BR
dc.description.unidadeFaculdade UnB Planaltina (FUP)-
dc.description.ppgPrograma de Pós-Graduação em Nanociência e Nanobiotecnologiapt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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