Skip navigation
Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/47693
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_HepatoprotectiveEffetcsFour.pdf7,61 MBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorRibeiro, Gislane dos Santos-
dc.contributor.authorMartins, Diegue Henrique Nascimento-
dc.contributor.authorGomes, João Victor Dutra-
dc.contributor.authorDavies, Noel William-
dc.contributor.authorFagg, Christopher William-
dc.contributor.authorSimeoni, Luiz Alberto-
dc.contributor.authorHomem de Mello, Mauricio-
dc.contributor.authorBatista, Pérola de Oliveira Magalhães Dias-
dc.contributor.authorSilveira, Dâmaris-
dc.contributor.authorFonseca-Bazzo, Yris Maria-
dc.date.accessioned2024-02-06T14:31:26Z-
dc.date.available2024-02-06T14:31:26Z-
dc.date.issued2023-09-26-
dc.identifier.citationRIBEIRO, Gislane dos Santos et al. Hepatoprotective effects of four Brazilian savanna species on acetaminophen-induced hepatotoxicity in HepG2 cells. Plants, [S. l.], v. 12, n. 19, 3393, 2023. DOI: https://doi.org/10.3390/plants12193393. Disponível em: https://www.mdpi.com/2223-7747/12/19/3393. Acesso em: 06 fev. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47693-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleHepatoprotective effects of four Brazilian savanna species on acetaminophen-induced hepatotoxicity in HepG2 cellspt_BR
dc.typeArtigopt_BR
dc.subject.keywordParacetamolpt_BR
dc.subject.keywordAtividade hepatotoxicidadept_BR
dc.subject.keywordFitoterapiapt_BR
dc.subject.keywordAtividade hepatoprotetorapt_BR
dc.rights.licenseCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/plants12193393pt_BR
dc.description.abstract1We investigated four Cerrado plant species, i.e., Cheiloclinium cognatum (Miers) A.C.Sm, Guazuma ulmifolia Lam., Hancornia speciosa Gomes, and Hymenaea stigonocarpa Mart. ex Hayne, against acetaminophen toxicity using an in vitro assay with HepG2 cells. The activity against acetaminophen toxicity was evaluated using different protocols, i.e., pre-treatment, co-treatment, and post-treatment of the cells with acetaminophen and the plant extracts. HepG2 cell viability after treatment with acetaminophen was 39.61 ± 5.59% of viable cells. In the pre-treatment protocol, the extracts could perform protection with viability ranging from 50.02 ± 15.24% to 78.75 ± 5.61%, approaching the positive control silymarin with 75.83 ± 5.52%. In the post-treatment protocol, all extracts and silymarin failed to reverse the acetaminophen damage. In the co-treatment protocol, the extracts showed protection ranging from 50.92 ± 11.14% to 68.50 ± 9.75%, and silymarin showed 77.87 ± 4.26%, demonstrating that the aqueous extracts of the species also do not increase the toxic effect of acetaminophen. This protection observed in cell viability was accompanied by a decrease in ROS. The extracts’ hepatoprotection can be related to antioxidant compounds, such as rutin and mangiferin, identified using HPLC-DAD and UPLC-MS/MS. The extracts were shown to protect HepG2 cells against future APAP toxicity and may be candidates for supplements that could be used to prevent liver damage. In the concomitant treatment using the extracts with APAP, it was demonstrated that the extracts do not present a synergistic toxicity effect, with no occurrence of potentiation of toxicity. The extracts showed considerable cytoprotective effects and important antioxidant characteristics.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6098-3852pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4541-9177pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4541-9177pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8011-6940pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1230-3207pt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Tasmania, Central Science Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Department of Botanypt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Health Sciences School, Pharmacy Departmentpt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Botânica (IB BOT)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticaspt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.