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Título: New fraternine analogues : evaluation of the antiparkinsonian effect in the model of Parkinson’s disease
Autor(es): Mayer, Andréia Biolchi
Amaral, Henrique de Oliveira
Oliveira, Danilo Gustavo R. de
Campos, Gabriel Avohay Alves
Ribeiro, Priscilla Galante
Fernandes, Solange Cristina Rego
Souza, Adolfo Carlos Barros de
Castro, Raffael Júnio Araújo de
Bocca, Anamélia Lorenzetti
Mortari, Márcia Renata
Afiliação do autor: University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
University of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology
University of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology
University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
Assunto: Parkinson, Doença de - tratamento
Peptídeos sintéticos
Vespa - veneno
Medicamentos
Coordenação motora
Data de publicação: Nov-2023
Editora: Elsevier Ltd.
Referência: MAYER, Andréia Biolchi et al. New fraternine analogues: evaluation of the antiparkinsonian effect in the model of Parkinson’s disease. Neuropeptides, [S. l.], v. 103, 102390, fev. 2024. DOI: https://doi.org/10.1016/j.npep.2023.102390.
Abstract: Venom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with promising effects for the treatment of Parkinson's disease. In the present paper, we synthesized three peptides bioinspired in fraternine: fra-10, fra-14, and fra-24. They were tested in the 6-OHDA-induced model of parkinsonism, quantifying motor coordination, levels of TH+ neurons in the substantia nigra pars compacta (SN), and inflammation mediators TNF-α, IL-6, and IL-1ß in the cortex. Peptides fra-14 and fra-10 improved the motor coordination in relation to 6-OHDA lesioned animals. However, most of the peptides were toxic in the doses applied. All three peptides reduced the intensity of the lesion induced rotations in the apomorphine test. Fra-24 higher dose increased the number of TH+ neurons in SN and reduced the concentration of TNF-α in the cortex of 6-OHDA lesioned mice. Overall, only the peptide fra-24 presented a neuroprotection effect on dopaminergic neurons of SN and a reduction of cytokine TNF-α levels, making it worthy of consideration for the treatment of PD.
Unidade Acadêmica: Instituto de Ciências Biológicas (IB)
Departamento de Ciências Fisiológicas (IB CFS)
Departamento de Biologia Celular (IB CEL)
DOI: https://doi.org/10.1016/j.npep.2023.102390
Versão da editora: https://www.sciencedirect.com/science/article/pii/S0143417923000719
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