Título:	New fraternine analogues : evaluation of the antiparkinsonian effect in the model of Parkinson’s disease
Autor(es):	Mayer, Andréia Biolchi Amaral, Henrique de Oliveira Oliveira, Danilo Gustavo R. de Campos, Gabriel Avohay Alves Ribeiro, Priscilla Galante Fernandes, Solange Cristina Rego Souza, Adolfo Carlos Barros de Castro, Raffael Júnio Araújo de Bocca, Anamélia Lorenzetti Mortari, Márcia Renata
Afiliação do autor:	University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology niversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology University of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology University of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunology University of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacology
Assunto:	Parkinson, Doença de - tratamento Peptídeos sintéticos Vespa - veneno Medicamentos Coordenação motora
Data de publicação:	Nov-2023
Editora:	Elsevier Ltd.
Referência:	MAYER, Andréia Biolchi et al. New fraternine analogues: evaluation of the antiparkinsonian effect in the model of Parkinson’s disease. Neuropeptides, [S. l.], v. 103, 102390, fev. 2024. DOI: https://doi.org/10.1016/j.npep.2023.102390.
Abstract:	Venom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with promising effects for the treatment of Parkinson's disease. In the present paper, we synthesized three peptides bioinspired in fraternine: fra-10, fra-14, and fra-24. They were tested in the 6-OHDA-induced model of parkinsonism, quantifying motor coordination, levels of TH+ neurons in the substantia nigra pars compacta (SN), and inflammation mediators TNF-α, IL-6, and IL-1ß in the cortex. Peptides fra-14 and fra-10 improved the motor coordination in relation to 6-OHDA lesioned animals. However, most of the peptides were toxic in the doses applied. All three peptides reduced the intensity of the lesion induced rotations in the apomorphine test. Fra-24 higher dose increased the number of TH+ neurons in SN and reduced the concentration of TNF-α in the cortex of 6-OHDA lesioned mice. Overall, only the peptide fra-24 presented a neuroprotection effect on dopaminergic neurons of SN and a reduction of cytokine TNF-α levels, making it worthy of consideration for the treatment of PD.
Unidade Acadêmica:	Instituto de Ciências Biológicas (IB) Departamento de Ciências Fisiológicas (IB CFS) Departamento de Biologia Celular (IB CEL)
DOI:	https://doi.org/10.1016/j.npep.2023.102390
Versão da editora:	https://www.sciencedirect.com/science/article/pii/S0143417923000719
Aparece nas coleções:	Artigos publicados em periódicos e afins

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