Título:	Clinical effectiveness of screening for age-related macular degeneration : a systematic review
Autor(es):	Gomes, Dalila Fernandes Curado, Daniel da Silva Pereira Gomes, Rosângela Maria Leite, Betânia Ferreira Ramos, Maíra Catharina Silva, Everton Nunes
ORCID:	https://orcid.org/0000-0002-2864-0806 https://orcid.org/0000-0002-5965-4194 https://orcid.org/0000-0003-3829-975X https://orcid.org/0000-0001-8747-4185
Afiliação do autor:	University of Brasilia, Graduate Program in Collective Health Ministry of Health, Department of Management and Incorporation of Health Technologies, Brasilia, Federal District, Brazil Federal University of Minas Gerais, Department of Social Pharmacy, College of Pharmacy University of Brasilia, Faculty of Health Sciences, Department of Pharmacy Federal University of Sao Paulo, Paulista School of Medicine, Department of Medicine University of Brasilia, Graduate Program in Collective Health University of Brasilia, Graduate Program in Collective Health University of Brasili, Faculty of Ceilandia,
Assunto:	Degeneração macular Tomografia Olhos - doenças Olhos - doenças - diagnóstico Retinopatia diabética
Data de publicação:	16-Nov-2023
Editora:	Plos One
Referência:	GOMES, Dalila Fernandes et al. Clinical effectiveness of screening for age-related macular degeneration: a systematic review. Plos One, [S. l.], 16 nov. 2023. DOI: https://doi.org/10.1371/journal.pone.0294398. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0294398. Acesso em: 31 jan. 2024.
Abstract:	Introduction Age-related macular degeneration (AMD) is an eye disease that occurs in patients over 50 years old. Early diagnosis enables timely treatment to stabilize disease progression. How-ever, the fact that the disease is asymptomatic in its early stages can delay treatment until it progresses. As such, screening in specific contexts can be an early detection tool to reduce the clinical and social impact of the disease. Objective Assess the effectiveness of screening methods for early detection of AMD in adults aged 50 years or older. Methods A systematic review of comparative observational studies on AMD screening methods in those aged 50 years or older, compared with no screening or any other strategy. A literature search was conducted in the MEDLINE (via PubMed), Embase, Cochrane Library and Lilacs database. Results A total of 5,290 studies were identified, three of which met the inclusion criteria and were selected for the systematic review. A total of 8,733 individuals (16,780 eyes) were included in the analysis. The screening methods assessed were based on optical coherence tomography (OCT) compared with color fundus photography, and OCT and telemedicine testing compared to a standard eye exam. Conclusion The systematized data are limited and only suggest satisfactory performance in early screening of the population at risk of developing AMD. OCT and the telemedicine technique showed promising results in AMD screening. However, methodological problems were iden tified in the studies selected and the level of evidence was considered low.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Farmácia (FS FAR) Faculdade UnB Ceilândia (FCE)
Programa de pós-graduação:	Programa de Pós-Graduação em Saúde Coletiva
Licença:	Copyright: © 2023 Gomes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/10.1371/journal.pone.0294398
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