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dc.contributor.authorEl-Chaer, William Khalil-
dc.contributor.authorTonet-Furioso, Audrey Cecília-
dc.contributor.authorMorais Junior, Gilberto Santos-
dc.contributor.authorSouza, Vinícius Carolino de-
dc.contributor.authorAvelar, Gleiciane Gontijo-
dc.contributor.authorHenriques, Adriane Dallanora-
dc.contributor.authorMoraes, Clayton Franco-
dc.contributor.authorNóbrega, Otávio de Tôledo-
dc.date.accessioned2024-01-22T11:30:17Z-
dc.date.available2024-01-22T11:30:17Z-
dc.date.issued2020-05-05-
dc.identifier.citationEL-CHAER, William Khalil et al. Serum levels of matrix metalloproteinase-1 in Brazilian patients with benign prostatic hyperplasia or prostate cancer. Current Gerontology and Geriatrics Research, [S. l.], v. 2020, Article ID 6012102, 7 p. DOI: https://doi.org/10.1155/2020/6012102. Disponível em: https://www.hindawi.com/journals/cggr/2020/6012102/. Acesso em: 22 jan. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47427-
dc.language.isoengpt_BR
dc.publisherHindawipt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSerum levels of matrix metalloproteinase-1 in Brazilian patients with benign prostatic hyperplasia or prostate cancerpt_BR
dc.typeArtigopt_BR
dc.subject.keywordPróstata - câncerpt_BR
dc.subject.keywordPróstata - doençaspt_BR
dc.subject.keywordHiperplasiapt_BR
dc.rights.licenseCopyright © 2020 William Khalil El-Chaer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_BR
dc.identifier.doihttps://doi.org/10.1155/2020/6012102pt_BR
dc.description.abstract1Metalloproteinases (MMPs) are involved in metastatic tumor processes, with changes in circulating levels detected in several cancer types. Here, we compare serum concentrations of metalloproteinase-1 (MMP-1) across individuals clinically diagnosed with prostate cancer (PCa) or benign prostatic hyperplasia (BPH), correcting results for the rs495366 single nucleotide polymorphism (SNP) that predisposes to differential MMP-1 levels. 196 men aged ≥50 years were followed at a university hospital urology outpatient clinic, with clinical, anthropometric, and rectal examinations performed by one urologist. Blood samples obtained prior to any clinical intervention provided baseline MMP-1 and total/free PSA levels as well as metabolic, hormonal, and inflammatory markers. +e SNP was genotyped by real-time PCR. Participants with medical and/or laboratory profile compatible with malignancy composed the PCa group when confirmed by the Gleason scale. As expected, A-allele homozygotes showed reduced levels of MMP-1. Genotype-adjusted analyses revealed the mean MMP-1 level as 2-fold higher in PCa carriers compared to BPH patients. No other differences were found according to the prostatic condition or genotypic distribution, except for the expected raise in total and free PSA levels in PCa. In conclusion, increased serum levels of MMP-1 were observed in this context of prostatic malignancy compared to a benign phenotype, regardless of a genetic influence.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1511-0387pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1775-7176pt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade Católica de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.contributor.affiliationUniversidade Católica de Brasíliapt_BR
dc.contributor.affiliationUniversidade de Brasíliapt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências da Saúdept_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Médicaspt_BR
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