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Universidade de Brasília
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dc.contributor.authorCavalcanti, Marilia Hermes-
dc.contributor.authorRoseira, João Paulo Santos-
dc.contributor.authorLeandro, Eliana dos Santos-
dc.contributor.authorArruda, Sandra Fernandes-
dc.date.accessioned2024-01-05T13:05:02Z-
dc.date.available2024-01-05T13:05:02Z-
dc.date.issued2022-01-26-
dc.identifier.citationCAVALCANTI, Marilia Hermes et al. Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats: impact on inflammatory response, lipid profile, and gut microbiota. PLoS ONE, [S. l.], v. 17, n. 1, e0262270, 2022. DOI: https://doi.org/10.1371/journal.pone.0262270. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262270. Acesso em: 05 jan. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47160-
dc.language.isoengpt_BR
dc.publisherPlospt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEffect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiotapt_BR
dc.typeArtigopt_BR
dc.subject.keywordDietaspt_BR
dc.subject.keywordCafépt_BR
dc.subject.keywordBilept_BR
dc.subject.keywordBifidobactériaspt_BR
dc.subject.keywordEscherichia colipt_BR
dc.subject.keywordObesidadept_BR
dc.subject.keywordLactobacilospt_BR
dc.rights.license© 2022 Cavalcanti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0262270pt_BR
dc.description.abstract1Coffee beans contain high polyphenol content, which have the potential to modulate the intestinal microbiota, and possibly attenuate weight gain and the associated dyslipidemia. This study investigated the effect of freeze-dried coffee solution (FCS) consumption on physiological parameters, lipid profile, and microbiota of Wistar rats fed a high-fat diet (HF) or control diet (CT). FCS combined with a high-fat diet increased the fecal and cecal Bifidobacterium spp. population and decreased the cecal Escherichia coli population and intestinal Il1b mRNA level. Regardless of the diet type, FCS increased the serum high-density lipoprotein cholesterol (HDL-C); however, it did not affect body weight, food intake, low-density lipoprotein, triglycerides, fecal bile acids, and intestinal Il6 mRNA levels. The high-fat diet increased weight gain, hepatic cholesterol and triglycerides, fecal bile acids, and the fecal and cecal Lactobacillus spp. population, and reduced food intake, the fecal E. coli population, and intestinal Il6 mRNA level. The results suggest that FCS consumption exhibits positive health effects in rats fed a high-fat diet by increasing Bifidobacterium spp. population and HDL-C reverse cholesterol transport, and by reducing Il1b mRNA level. However, FCS administration at a dose of 0.39 g/100 g diet over an eight-week period was not effective in controlling food intake, and consequently, preventing weight gain in rats of high-fat diet-induced obesity model.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9826-6004pt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutritionpt_BR
dc.contributor.affiliationUniversidade Federal de Viçosa, Department of Animal Sciencept_BR
dc.contributor.affiliationUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutritionpt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutritionpt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Nutrição (FS NUT)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Nutrição Humanapt_BR
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