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Universidade de Brasília
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dc.contributor.authorAlmeida, Edson A. T.-
dc.contributor.authorNunes, Ricardo Ferreira-
dc.contributor.authorAguiar, Beatriz Regina Lima de-
dc.contributor.authorReis, Paula Elaine Diniz dos-
dc.contributor.authorGratieri, Taís-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.date.accessioned2024-01-03T14:53:34Z-
dc.date.available2024-01-03T14:53:34Z-
dc.date.issued2021-07-09-
dc.identifier.citationALMEIDA, Edson A. T. et al. Aqueous-based nanoemulsion containing (-)-α-bisabolol for topical treatment of skin burns. Current Cosmetic Science, [S. l.], v. 1, n. 1, e090721194664, 2022. DOI: 10.2174/2666779701666210709113113.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47154-
dc.language.isoengpt_BR
dc.publisherBentham Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.titleAqueous-based nanoemulsion containing (-)-α-bisabolol for topical treatment of skin burnspt_BR
dc.typeArtigopt_BR
dc.subject.keywordPele - ferimentos e lesõespt_BR
dc.subject.keywordNanoemulsãopt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordCamomila - florespt_BR
dc.identifier.doi10.2174/2666779701666210709113113pt_BR
dc.relation.publisherversionhttps://www.eurekaselect.com/article/116601pt_BR
dc.description.abstract1Background: α-Bisabolol (BIS) is a sesquiterpene extracted from the chamomile flowers, whose use to topically treat burn skin has been reported. High lipophilicity of BIS, however, is a problem for both skin application and washing. Objective: The present study aimed to prepare and characterize a stable and safe aqueous-based nanoemulsion to incorporate BIS and favor skin penetration focusing on skin burns' topical treatment. Methods: Oil-in-water nanoemulsions were obtained from a pseudo-ternary phase diagram. The selected nanoemulsion was characterized (droplet size, PDI, and zeta potential), and the stability was assessed for 60 days at 6ºC and room temperature. The irritability of the formulation was determined by HET-CAM. Skin permeation studies were carried out in vitro intact skin, hot water burn skin, and hot plate burn skin. Results: The nanoemulsion incorporated 1% (w/w) BIS, presented droplets' size of 14.0±0.8 nm (PDI= 0.13±0.02), the zeta potential of +7.5±1.9 mV, and was physically stable over 60 days. The HET-CAM did not show any irritability process provided by the nanoformulation. In the skin permeation experiments, when compared to an oily control solution of BIS, nanoemulsion increased 3.7-fold penetration of the drug in intact skin, likely because the nanoformulation acted as an absorption drug enhancer. On a hot water burn skin model, the increase in drug penetration was 1.7-fold, and in the hot plate burn skin, it was 2.3-fold. Conclusion: The nanoemulsion seems to be a promising alternative for skin burns' topical treatment using this natural active.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0394-0500pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9782-3366pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6481-2364pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9167-6852pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1924-7885pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Enfermagem (FS ENF)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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