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dc.contributor.authorGomes, Deizilene de Souza Barbosa-
dc.contributor.authorPatermo, Leonardo Giordano-
dc.contributor.authorSantos, Aline B. S.-
dc.contributor.authorBarbosa, Débora P. P.-
dc.contributor.authorHoltz, Beatriz M.-
dc.contributor.authorSouza, Maysa R.-
dc.contributor.authorSouza, Rafaianne Q. Moraes-
dc.contributor.authorGaray, Aisel V.-
dc.contributor.authorAndrade, Laise R. de-
dc.contributor.authorSartoratto, Patricia P. C.-
dc.contributor.authorMertz, Damien-
dc.contributor.authorVolpato, Gustavo T.-
dc.contributor.authorFreitas, Sonia M.-
dc.contributor.authorSoler, Maria Aparecida Godoy-
dc.date.accessioned2023-10-24T15:21:28Z-
dc.date.available2023-10-24T15:21:28Z-
dc.date.issued2023-05-01-
dc.identifier.citationGOMES, Deizilene S. B. et al. UV-accelerated synthesis of gold nanoparticle–pluronic nanocomposites for X-ray computed tomography contrast enhancement. Polymers, [S.l.], v. 15, n. 9, 2163, 2023. DOI: https://doi.org/10.3390/polym15092163. Disponível em: https://www.mdpi.com/2073-4360/15/9/2163. Acesso em: 24 out. 2023.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46724-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleUV-accelerated synthesis of gold nanoparticle–pluronic nanocomposites for X-ray computed tomography contrast enhancementpt_BR
dc.typeArtigopt_BR
dc.subject.keywordNanopartículas de ouropt_BR
dc.subject.keywordPluronic F127pt_BR
dc.subject.keywordNanocompósitospt_BR
dc.subject.keywordTomografia computadorizadapt_BR
dc.subject.keywordCitotoxicidadept_BR
dc.rights.licenseCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).-
dc.identifier.doihttps://doi.org/10.3390/polym15092163pt_BR
dc.description.abstract1Eco-friendly chemical methods using FDA-approved Pluronic F127 (PLU) block copolymer have garnered much attention for simultaneously forming and stabilizing Au nanoparticles (AuNPs). Given the remarkable properties of AuNPs for usage in various fields, especially in biomedicine, we performed a systematic study to synthesize AuNP-PLU nanocomposites under optimized conditions using UV irradiation for accelerating the reaction. The use of UV irradiation at 254 nm resulted in several advantages over the control method conducted under ambient light (control). The AuNP-PLU-UV nanocomposite was produced six times faster, lasting 10 min, and exhibited lower size dispersion than the control. A set of experimental techniques was applied to determine the structure and morphology of the produced nanocomposites as affected by the UV irradiation. The MTT assay was conducted to estimate IC50 values of AuNP-PLU-UV in NIH 3T3 mouse embryonic fibroblasts, and the results suggest that the sample is more compatible with cells than control samples. Afterward, in vivo maternal and fetal toxicity assays were performed in rats to evaluate the effect of AuNP-PLU-UV formulation during pregnancy. Under the tested conditions, the treatment was found to be safe for the mother and fetus. As a proof of concept or application, the synthesized Au:PLU were tested as contrast agents with an X-ray computed tomography scan (X-ray CT).pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7716-0318pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2144-5004pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3639-5740pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6947-1087pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6745-8978pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4753-3264pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7562-4980pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0444-873Xpt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivospt_BR
dc.contributor.affiliationInstituto Federal de Educação, Ciência e Tecnologia de Rôndoniapt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Quimica, Laboratorio de Pesquisa em Polimeros e Nanomateriaispt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivospt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivospt_BR
dc.contributor.affiliationFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicologypt_BR
dc.contributor.affiliationFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicologypt_BR
dc.contributor.affiliationFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicologypt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Biofisica Molecularpt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Ciências Biologicaspt_BR
dc.contributor.affiliationUniversidade Federal de Goiás, Instituto de Quimicapt_BR
dc.contributor.affiliationInstitut de Physique et Chimie des Materiaux de Strasbourg (IPCMS), UMR-7504 CNRS-Universite de Strasbourgpt_BR
dc.contributor.affiliationFederal University of Mato Grosso, Institute of Biological and Health Sciences, Laboratory of System Physiology and Reproductive Toxicologypt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Laboratório de Biofisica Molecularpt_BR
dc.contributor.affiliationUniversidade de Brasilia, Instituto de Física, Laboratório de Nanofilmes e Nano Dispositivospt_BR
dc.description.unidadeInstituto de Física (IF)pt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
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