Solution and solid behavior of mono and binuclear zinc(II) and nickel(II) complexes with dithiocarbazates : X-ray analysis, mass spectrometry and cytotoxicity against cancer cell lines

Cavalcante, Cássia de Queiroz Oliveira; Arcanjo, Daniel da Silva; Silva, Guilherme Guimarães da; Oliveira, Diêgo Madureira de; Gatto, Claudia Cristina

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Campo DC	Valor	Idioma
dc.contributor.author	Cavalcante, Cássia de Queiroz Oliveira	-
dc.contributor.author	Arcanjo, Daniel da Silva	-
dc.contributor.author	Silva, Guilherme Guimarães da	-
dc.contributor.author	Oliveira, Diêgo Madureira de	-
dc.contributor.author	Gatto, Claudia Cristina	-
dc.date.accessioned	2023-10-24T13:26:41Z	-
dc.date.available	2023-10-24T13:26:41Z	-
dc.date.issued	2019-07-01	-
dc.identifier.citation	CAVALCANTE, Cássia de Q. O. Solution and solid behavior of mono and binuclear zinc(II) and nickel(II) complexes with dithiocarbazates: X-ray analysis, mass spectrometry and cytotoxicity against cancer cell lines. New Journal of Chemistry,, n. 28, 43, 11209-11221, 2019. DOI: 10.1039/c9nj01814j rsc.li/njc.	pt_BR
dc.identifier.uri	http://repositorio2.unb.br/jspui/handle/10482/46722	-
dc.language.iso	eng	pt_BR
dc.publisher	The Royal Society of Chemistry and the Centre National de la Recherche Scientifique	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Solution and solid behavior of mono and binuclear zinc(II) and nickel(II) complexes with dithiocarbazates : X-ray analysis, mass spectrometry and cytotoxicity against cancer cell lines	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Ditiocarbazatos	pt_BR
dc.subject.keyword	Raios X	pt_BR
dc.subject.keyword	Espectrometria de massa	pt_BR
dc.subject.keyword	Citotoxicidade	pt_BR
dc.subject.keyword	Câncer	pt_BR
dc.identifier.doi	10.1039/c9nj01814j rsc.li/njc	pt_BR
dc.relation.publisherversion	https://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj01814j	pt_BR
dc.description.abstract1	The current work reports the synthesis and investigation by physical-chemistry and spectroscopic methods of three dithiocarbazates (2-acetylpyridine-S-allyl-dithiocarbazate – HL1 ; 2-acetylpyridine-S-p-bromobenzyl-dithiocarbazate – HL2 ; and 2-acetylpyridine-S-p-nitrobenzyl-dithiocarbazate – HL3) and six novel metal complexes derived from these Schiff-bases. Four crystal structures of the complexes are reported. The single crystal X-ray study showed two binuclear zinc(II) complexes with symmetrical and asymmetrical acetate bridges resulting in different coordination spheres. Another zinc(II) complex and three nickel(II) complexes present dithiocarbazates tridentate with NNS-donor atoms and octahedral geometry to the metal centers. The mass spectrometry data indicated the presence of the molecular ions [M + H]+ and characteristic fragments of the compounds. All characterization indicated the same behavior of the compounds as a solid and in solution. The biological activity of the zinc(II) and nickel(II) salts, the free dithiocarbazate ligands and their metal complexes was evaluated by assays with carcinoma mammary MDA-MB-231 cells. The results revealed that the free dithiocarbazates present great in vitro antitumor activity, which is increased after the complexation with zinc, with emphasis on the dimeric complex (1), which had an IC50 of 2.0 mM and exhibits more potential inhibition of tumor cell growth than the nickel(II) complexes.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-6044-1954	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-3736-6861	pt_BR
dc.contributor.affiliation	University of Brasília, Institute of Chemistry, Laboratory of Inorganic Synthesis and Crystallography	pt_BR
dc.contributor.affiliation	University of Brasília, Laboratory of Cancer	pt_BR
dc.contributor.affiliation	University of Brasília, Laboratory of Cancer	pt_BR
dc.contributor.affiliation	University of Brasília, Laboratory of Cancer	pt_BR
dc.contributor.affiliation	University of Brasília, Institute of Chemistry, Laboratory of Inorganic Synthesis and Crystallography	pt_BR
dc.description.unidade	Instituto de Química (IQ)	pt_BR
dc.description.unidade	Faculdade UnB Ceilândia (FCE)	pt_BR
dc.description.ppg	Programa de Pós-Graduação em Ciências e Tecnologias em Saúde	pt_BR
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