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dc.contributor.authorSousa, José Diego Brito-
dc.contributor.authorPeixoto, Henry Maia-
dc.contributor.authorDevine, Angela-
dc.contributor.authorSilva Neto, Alexandre V.-
dc.contributor.authorBalieiro, Patricia C. S.-
dc.contributor.authorSampaio, Vanderson S.-
dc.contributor.authorSilva, Sheila Vitor-
dc.contributor.authorMendes, Maxwell O.-
dc.contributor.authorSouza, Brenda K. A.-
dc.contributor.authorLacerda, Marcus V. G.-
dc.contributor.authorMonteiro, Wuelton M.-
dc.date.accessioned2023-10-11T14:32:18Z-
dc.date.available2023-10-11T14:32:18Z-
dc.date.issued2022-03-24-
dc.identifier.citationPLOS Neglected Tropical Diseases, mar. 2022. DOI: https://doi.org/10.1371/journal.pntd.0010325. Disponível em: https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0010325.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46664-
dc.language.isoengpt_BR
dc.publisherPlospt_BR
dc.rightsAcesso Abertopt_BR
dc.titleReal-life quantitative G6PD screening in Plasmodium vivax patients in the Brazilian Amazon : a cost-effectiveness analysispt_BR
dc.typeArtigopt_BR
dc.subject.keywordPlasmodium vivaxpt_BR
dc.subject.keywordDeficiência de glicose-6-fosfato desidrogenasept_BR
dc.rights.licenseCopyright: © 2022 Brito-Sousa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0010325pt_BR
dc.description.abstract1Background As quantitative glucose 6-phosphate dehydrogenase deficiency (G6PDd) screening tools are evaluated in operational studies, questions remain as to whether they are cost-effective. Here, a cost-effectiveness analysis (CEA) was performed to estimate the Incremental Cost-effectiveness Ratio (ICER) of the introduction of quantitative screening test to detect G6PDd among P. vivax carriers in two municipalities in the Brazilian Amazon. Methodology/Principal findings This cost-effectiveness analysis evaluated the use of the Standard G6PD quantitative screening test in vivax malaria treatment units in two municipalities of the Brazilian Amazon. Using the perspective of the Brazilian public health system, the analysis was performed for the outcome ‘PQ-associated hospitalization avoided’, based on a decision tree model. The results indicated that the G6PDd screening strategy compared with the routine strategy was highly cost-effective, with an ICER of US$495 per additional hospitalization avoided, which represented less than 8% of one Brazilian gross domestic product per capita (US$6,822). The uncertainties evaluated in the sensitivity analysis did not significantly affect the ICER identified in the base-case. Conclusions/Significance This cost-effectiveness analysis showed the quantitative G6PD testing was effective in avoiding PQ-associated hospitalizations. The incorporation of G6PD screening is of paramount importance towards P. vivax malaria elimination in the Amazon to promote the safe use of primaquine and tafenoquine.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0848-1940pt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúdept_BR
dc.contributor.affiliationUniversidade de Brasilia, Faculdade de Medicinapt_BR
dc.contributor.affiliationCharles Darwin University, Global and Tropical Health Division, Menzies School of Health Researchpt_BR
dc.contributor.affiliationUniversity of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Healthpt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúdept_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúdept_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúdept_BR
dc.contributor.affiliationFundação de Vigilância em Saúde Dr Rosemary Costa Pinto–FVS-RCPpt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationUniversidade Federal do Amazonas–UFAM, Escola de Enfermagem de Manauspt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationInstituto Leônidas & Maria Deane–ILMD, Fundação Oswaldo Cruzpt_BR
dc.contributor.affiliationInstituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Douradopt_BR
dc.contributor.affiliationUniversidade do Estado do Amazonas, Escola Superior de Ciências da Saúdept_BR
dc.description.unidadeFaculdade de Medicina (FMD)pt_BR
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