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dc.contributor.authorSouza, Danielle Galdino de-
dc.contributor.authorSantos, Débora Silva-
dc.contributor.authorSimon, Karina Smidt-
dc.contributor.authorMorais, José Athayde Vasconcelos-
dc.contributor.authorCoelho, Luísa Coutinho-
dc.contributor.authorPacheco, Thyago José Arruda-
dc.contributor.authorAzevedo, Ricardo Bentes-
dc.contributor.authorBocca, Anamélia Lorenzetti-
dc.contributor.authorMelo-Silva, César Augusto-
dc.contributor.authorLongo, João Paulo Figueiró-
dc.date.accessioned2023-07-10T14:29:53Z-
dc.date.available2023-07-10T14:29:53Z-
dc.date.issued2022-
dc.identifier.citationSOUZA, Danielle Galdino de Souza; SANTOS, Débora Silva Santos; SIMON, Karina Smidt Simon; MORAIS, José Athayde Vasconcelos COELHO, Luísa Coutinho Coelho; PACHECO, Thyago José Arruda; AZEVEDO, Ricardo Bentes; BOCCA, Anamélia Lorenzetti; MELO-SILVA, César Augusto Melo-Silva; LONGO, João Paulo Figueiró. Fish oil nanoemulsion supplementation attenuates bleomycin-induced pulmonary fibrosis BALB/c Mice. Nanomaterials, [S.l.], v. 12, 1683, 2022. DOI: https://doi.org/10.3390/nano12101683. Disponível em: https://www.mdpi.com/2079-4991/12/10/1683. Acesso em: 09 jul. 2023.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46042-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleFish oil nanoemulsion supplementation attenuates bleomycin-induced pulmonary fibrosis BALB/c Micept_BR
dc.typeArtigopt_BR
dc.subject.keywordNanoemulsãopt_BR
dc.subject.keywordFibrose pulmonarpt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordÓleos de peixept_BR
dc.rights.license© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/nano12101683pt_BR
dc.description.abstract1Diets rich in omega-3 or -6 fatty acids will produce different profiles for cell membranes phospholipid constitutions. Omegas 3 and 6 are part of the diet and can modulate the inflammatory profile. We evaluated the effects of the oral absorption of fish oil, when associated with a lipid nanoemulsion in an experimental pulmonary inflammatory model. Pulmonary fibrosis is a disease associated with excessive extracellular matrix deposition. We determined to investigate the morphophysiological mechanisms in mice that were pretreated after induction with bleomycin (BLM). The pretreatment was for 21 days with saline solution, sunflower oil (SO), fish oil (FO), and fish oil nanoemulsion (NEW3). The animals received a daily dose of 50 mg/Kg of docosahexaenoic acid DHA and 10 mg/Kg eicosapentaenoic (EPA) (100 mg/Kg), represented by a daily dose of 40 µL of NEW3. The blank group was treated with the same amount daily (40 µL) during the 21 days of pretreatment. The animals were treated with SO and FO, 100 mg/Kg (containing 58 mg/Kg of polyunsaturated fats/higher% linoleic acid) and 100 mg/Kg (50 mg/Kg of DHA and 10 mg/Kg EPA), respectively. A single dose of 5 mg/mL (50 µL) bleomycin sulfate, by the intratracheal surgical method in BALB/cAnNTac (BALB/c). NEW3 significantly reduced fibrotic progression, which can be evidenced by the protection from loss of body mass, increase in respiratory incursions per minute, decreased spacing of alveolar septa, decreased severity of fibrosis, and changes in the respiratory system. NEW3 attenuated the inflammatory changes developed in the experimental model of pulmonary fibrosis, while group SO showed a significant increase in inflammatory changes. This concluded that the presented results demonstrated that is possible to positively modulate the immune and inflamamtory response to an external agressor, by changing the nutitional intake of specific fatty acids, such as omega-3 placed in fish oil. Moreover, these benefits can be improved by the nanoencapsulation of fish oil in lipid nanoemulsions.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3432-0769pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2395-7748pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8090-0644pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2137-9588pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3323-5300pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3544-6999pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Applied Immunology Laboratory, Cell Biology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Applied Immunology Laboratory, Cell Biology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Applied Immunology Laboratory, Cell Biology Departmentpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Respiratory Physiology Laboratorypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Science, Nanobiotechnology Laboratory, Genetics & Morphology Departmentpt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Genética e Morfologia (IB GEM)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Nanociência e Nanobiotecnologiapt_BR
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