| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Serra, Lucieny Silva Martins | - |
| dc.contributor.author | Araújo, Juliana Gusmão de | - |
| dc.contributor.author | Novanta, Gabriela | - |
| dc.contributor.author | Lauand, Lucas | - |
| dc.contributor.author | Silva, Eduardo Magalhães da | - |
| dc.contributor.author | Kückelhaus, Selma Aparecida Souza | - |
| dc.contributor.author | Sampaio, André Luiz Lopes | - |
| dc.date.accessioned | 2022-11-22T21:38:05Z | - |
| dc.date.available | 2022-11-22T21:38:05Z | - |
| dc.date.issued | 2022-06-14 | - |
| dc.identifier.citation | SERRA, Lucieny Silva Martins et. al. Melatonin prevents age-related hearing loss in the murin experimental model. Brazilian Journal of Otorhinolaryngology, Campinas, 2022. DOI 10.1016/j.bjorl.2022.06.002. Disponível em: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/45209 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Elsevier | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Melatonin prevents age-related hearing loss in the murin experimental model | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Melatonina | pt_BR |
| dc.subject.keyword | Perda auditiva | pt_BR |
| dc.subject.keyword | Células ciliadas externas | pt_BR |
| dc.rights.license | 1808-8694/© 2022 Associacão Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Fonte: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1016/j.bjorl.2022.06.002 | pt_BR |
| dc.description.abstract1 | Objective: The present study aimed to perform a morphological and morphometric analysis of cochlear structures of C57BL/6J mice receiving oral melatonin for a 12-month period. Methods: 32 male C57BL/6J were divided into control and melatonin groups. Control received saline and ethanol solution and melatonin group, 50 L of 10 mg of melatonin/kg/day orally for a 12-month period. After de experiment the animals were sacrificed into a 40% concentration of CO2 chamber, and the blades were morphological and morphometrically analyzed. Results: The melatonin group revealed a higher median density of viable cells (45 ± 10.28 cells/100 m2, 31---73, vs. 32 ± 7.47 cells/100 m2, 25---48). The median area of stria vascularis was 55.0 ± 12.27 cells/100 m2 (38---80) in the control, and 59.0 ± 16.13 cells/100 m2 (40---134) in the melatonin group. The morphometric analysis of the spiral ligament reveals a higher median of total viable neurons in the melatonin (41 ± 7.47 cells/100 m2, 27---60) than in the control group (31 ± 5.68 cells/100 m2, 21---44). Conclusion: Although melatonin is a potent antioxidant, it does not completely neutralize the occurrence of presbycusis; however, it may delay the onset of this condition. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-8113-7222 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-7853-3016 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-4494-3353 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-2777-9494 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-5132-8370 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-7677-772X | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-7611-1303 | pt_BR |
| dc.contributor.email | mailto:lucienymserra@gmail.com | pt_BR |
| dc.contributor.email | mailto:andremarjy@uol.com.br | pt_BR |
| dc.description.unidade | Faculdade de Medicina (FM) | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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