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Universidade de Brasília
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dc.contributor.authorRamos, Doralina do Amaral Rabello-
dc.contributor.authorAraujo, Antonio Roberto Lucena-
dc.contributor.authorSilva, Juliana Carvalho Rocha Alves-
dc.contributor.authorEira, Vinícius Burnett Aboud Souza da-
dc.contributor.authorVasconcellos, Maria Catarina Cals de-
dc.contributor.authorOliveira, Fábio Morato de-
dc.contributor.authorRêgo, Eduardo Magalhães-
dc.contributor.authorAraujo, Felipe Saldanha de-
dc.contributor.authorPittella-Silva, Fabio-
dc.date.accessioned2022-10-04T15:38:25Z-
dc.date.available2022-10-04T15:38:25Z-
dc.date.issued2015-
dc.identifier.citationRABELLO, Doralina do Amaral et al. Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia. Blood Cells, Molecules, and Diseases, [S.l.], v. 54, n. 1, p. 97-102, 2015. DOI: https://doi.org/10.1016/j.bcmd.2014.07.013.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/44983-
dc.language.isoInglêspt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Restritopt_BR
dc.titleOverexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemiapt_BR
dc.typeArtigopt_BR
dc.subject.keywordLeucemia linfocítica crônica (LLC)pt_BR
dc.subject.keywordHistonaspt_BR
dc.subject.keywordMetiltransferasept_BR
dc.subject.keywordExpressão gênicapt_BR
dc.subject.keywordCitogenéticapt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bcmd.2014.07.013pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1079979614000928?via%3Dihubpt_BR
dc.description.abstract1EZH2, a histone methyltransferase, is overexpressed in several human tumors, but whether it exerts any impact in chronic lymphocytic leukemia (CLL) remains unknown. We used real time PCR to investigate the expression profile of EZH1 and EZH2 in 59 CLL patients, 10 samples of purified B-cells from healthy donors and 12 normal adult tissues. EZH2 was overexpressed in CLL patients and correlates with high white blood cell count, ZAP-70 expression and chromosomal abnormalities. EHZ1 expression does not correlate with CLL progression. EZH2 overexpression is related to a poor prognosis of CLL and could be a useful tool to assess its aggressiveness.pt_BR
dc.contributor.affiliationUniversidade de Brasília, Faculdade de Ciências da Saúde, Laboratório de Patologia Molecular do Câncerpt_BR
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