Antimicrobial resistance among leprosy patients in Brazil : real-world data based on the national surveillance plan

Andrade, Elaine Silva Nascimento; Brandão, Jurema Guerrieri; Silva, Juliana Souza da; Coriolano, Carmelita Ribeiro Filha; Rosa, Patricia Sammarco; Moraes, Milton Ozório; Ferreira, Cynthia de Oliveira; Gomes, Ciro Martins; Araújo, Wildo Navegantes de

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Campo DC	Valor	Idioma
dc.contributor.author	Andrade, Elaine Silva Nascimento	-
dc.contributor.author	Brandão, Jurema Guerrieri	-
dc.contributor.author	Silva, Juliana Souza da	-
dc.contributor.author	Coriolano, Carmelita Ribeiro Filha	-
dc.contributor.author	Rosa, Patricia Sammarco	-
dc.contributor.author	Moraes, Milton Ozório	-
dc.contributor.author	Ferreira, Cynthia de Oliveira	-
dc.contributor.author	Gomes, Ciro Martins	-
dc.contributor.author	Araújo, Wildo Navegantes de	-
dc.date.accessioned	2022-09-22T20:07:07Z	-
dc.date.available	2022-09-22T20:07:07Z	-
dc.date.issued	2022-04	-
dc.identifier.citation	ANDRADE, Elaine Silva Nascimento et al. Antimicrobial resistance among leprosy patients in Brazil: real-world data based on the national surveillance plan. Antimicrobial Agents and Chemotherapy, v. 66, n. 5, abr. 2022. DOI 10.1128/aac.02170-21. Disponível em: https://journals.asm.org/doi/10.1128/aac.02170-21. Acesso em: 22 set. 2022.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/44874	-
dc.language.iso	Inglês	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Antimicrobial resistance among leprosy patients in Brazil : real-world data based on the national surveillance plan	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Resistência a drogas	pt_BR
dc.subject.keyword	Hanseníase	pt_BR
dc.subject.keyword	DNA	pt_BR
dc.identifier.doi	https://doi.org/10.1128/aac.02170-21	pt_BR
dc.relation.publisherversion	https://journals.asm.org/doi/10.1128/aac.02170-21	pt_BR
dc.description.abstract1	Brazil ranks second among countries for new cases and first for relapse cases of leprosy worldwide. The Mycobacterium leprae Resistance Surveillance Plan was established. We aimed to present the results of a 2-year follow-up of the National Surveillance Plan in Brazil. A cross-sectional study of leprosy cases was performed to investigate antimicrobial resistance (AMR) in Brazil from October 2018 to September 2020. Molecular screening targeting genes related to dapsone (folP1), rifampin (rpoB), and ofloxacin resistance (gyrA) was performed. During the referral period, 63,520 active leprosy patients were registered in Brazil, and 1,183 fulfilled the inclusion criteria for molecular AMR investigation. In total, only 16 (1.4%) patients had genetic polymorphisms associated with AMR. Of these, 8 (50%) had cases of leprosy relapse, 7 (43.8%) had cases of suspected therapeutic failure with standard treatment, and 1 (6.2%) was a case of new leprosy presentation. M. leprae strains with AMR-associated mutations were found for all three genes screened. Isolates from two patients showed simultaneous resistance to dapsone and rifampin, indicating multidrug resistance (MDR). No significant relationship between clinical variables and the presence of AMR was identified. Our study revealed a low frequency of AMR in Brazil. Isolates were resistant mainly to dapsone, and a very low number of isolates were resistant to rifampin, the main bactericidal agent for leprosy, or presented MDR, reinforcing the importance of the standard World Health Organization multidrug therapy. The greater frequency of AMR among relapsed patients supports the need to constantly monitor this group.	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-8066-8283	pt_BR
dc.identifier.orcid	https://orcid.org/0000-0002-3069-6884	pt_BR
dc.description.unidade	Faculdade de Medicina (FM)	-
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