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dc.contributor.authorAlmeida, Carolane de Macêdo-
dc.contributor.authorMarcon, Pedro Henrique Salgado-
dc.contributor.authorNascimento, Erica Cristina Moreno-
dc.contributor.authorMartins, João Batista Lopes-
dc.contributor.authorChagas, Marcio A. S.-
dc.contributor.authorFujimori, Mahmi-
dc.contributor.authorMarchi, Patrícia Gelli Feres De-
dc.contributor.authorFrança, Eduardo L.-
dc.contributor.authorHonorio-França, Adenilda C.-
dc.contributor.authorGatto, Claudia Cristina-
dc.date.accessioned2022-09-14T19:09:32Z-
dc.date.available2022-09-14T19:09:32Z-
dc.date.issued2022-05-30-
dc.identifier.citationALMEIDA, Carolane M. et al. Organometallic gold (III) and platinum (II) complexes with thiosemicarbazone: structural behavior, anticancer activity, and molecular docking. Applied Organometallic Chemistry, v. 26, n. 8, art. e6761, ago. 2022. DOI 10.1002/aoc.6761. Disponível em: https://onlinelibrary.wiley.com/journal/10990739. Acesso em: 14 set. 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/44816-
dc.language.isoInglêspt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleOrganometallic gold (III) and platinum (II) complexes with thiosemicarbazone : structural behavior, anticancer activity, and molecular dockingpt_BR
dc.typeArtigopt_BR
dc.subject.keywordAtividade anticâncerpt_BR
dc.subject.keywordComplexos organometálicospt_BR
dc.subject.keywordTiossemicarbazonapt_BR
dc.identifier.doihttps://doi.org/10.1002/aoc.6761pt_BR
dc.description.abstract1This study reports the synthesis and characterization of two new organometallic Au (III) and Pt (II) complexes with 2-acetylthiophene-N(3)- methylthiosemicarbazone (HL). The characterization of the compounds was performed by single-crystal X-ray diffraction and spectroscopic techniques (Fourier transform infrared (FT-IR), UV–Vis, electrospray ionization (ESI)(+)-mass spectrometry (MS), and nuclear magnetic resonance (NMR)). The MS data indicated the presence in the solution of the molecular ion [H2L]+ and characteristic fragmentations of the ligand. The thiosemicarbazone is coordinated to the Au (III) and Pt (II) in tridentate mode through the CNS chelating system. The two metal atoms show a distorted square geometry including chloride ion or triphenylphosphine to complete the coordination sphere. The 3D Hirshfeld surface and the 2D fingerprint results were analyzed quantitatively to verify interactions upon the molecular packing. The biological activity of the free thiosemicarbazone and their complexes have been evaluated against the MCF-7 human cancer cell line. Molecular docking was used to predict the inhibitory activity of the compounds.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9531-6432pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9950-1128pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1365-177Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8677-3239pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0763-6514pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1646-8738pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7940-4478pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1854-5397pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0452-9804pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3736-6861pt_BR
dc.contributor.emailmailto:ccgatto@unb.brpt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
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