Título:	Can the Brazilian caffeine expectancy questionnaires differentiate the CYP1A2 and ADORA2A gene polymorphisms? : an exploratory study with Brazilian athletes
Autor(es):	Mendes, Guilherme Falcão Reis, Caio Eduardo Gonçalves Nakano, Eduardo Yoshio Spineli, Higor Barreto, Gabriel Noronha, Natália Yumi Watanabe, Lígia Moriguchi Nonino, Carla Barbosa Araujo, Gustavo Gomes de Saunders, Bryan Zandonadi, Renata Puppin
E-mail do autor:	mailto:guile.fm@gmail.com mailto:renatapz@yahoo.com.br
ORCID:	https://orcid.org/0000-0003-4985-6996 https://orcid.org/0000-0001-7260-9497 https://orcid.org/0000-0002-9071-8512 https://orcid.org/0000-0001-9589-8586 https://orcid.org/0000-0001-7498-6165 https://orcid.org/0000-0003-0995-9077 https://orcid.org/0000-0003-0370-3089
Assunto:	Cafeína Receptores A2 de adenosina Esforço físico Atletas - aspectos fisiológicos
Data de publicação:	16-Ago-2022
Editora:	MDPI
Referência:	MENDES, Guilherme Falcão et al. Can the Brazilian caffeine expectancy questionnaires differentiate the CYP1A2 and ADORA2A gene polymorphisms?: an exploratory study with Brazilian athletes. Nutrients, Basel, v. 14, n.16, art. 3355, 2022. DOI 10.3390/nu14163355. Disponível em: https://www.mdpi.com/2072-6643/14/16/3355. Acesso em: 13 set. 2022.
Abstract:	This study investigated the ability of the Brazilian Caffeine Expectancy Questionnaire (CaffEQ-BR), full and brief versions, to differentiate genetic profiles regarding the polymorphisms of the CYP1A2 (rs 762551) and ADORA2A (rs 5751876) genes in a cohort of Brazilian athletes. Onehundred and fifty participants were genotyped for CYP1A2 and ADORA2A. After the recruitment and selection phase, 71 (90% male and 10% female, regular caffeine consumers) completed the CaffEQ-BR questionnaires and a self-report online questionnaire concerning sociodemographic data, general health status, and frequency of caffeine consumption. The order of completion of the CaffEQBR questionnaires was counterbalanced. The concordance between the full and brief versions of the CaffEQ-BR was analyzed using the intraclass correlation coefficient (ICC). To determine the discriminatory capacity of the questionnaires for genotype, the receiver operating characteristic (ROC) curve was applied for sensitivity and specificity (significance level of 5%). Mean caffeine intake was 244 161 mg day􀀀1. The frequency of AA genotypes for CYP1A2 was 47.9% (n = 34) and 52.1% (n = 37) for C-allele carriers (AC and CC). The frequencies of TT genotypes for ADORA2A were 22.7% (n = 15) and 77.3% (n = 51) for C-allele carriers (TC and CC). All CaffEQ-BR factors, for the full and brief versions, were ICCs > 0.75, except for factor 6 (anxiety/negative effects; ICC = 0.60), and presented ROC curve values from 0.464 to 0.624 and 0.443 to 0.575 for CYP1A2 and ADORA2A. Overall, the CaffEQ-BR (full and brief versions) did not show discriminatory capacity for CYP1A2 and ADORA2A gene polymorphisms. In conclusion, the CaffEQ-BR was not able to differentiate genotypes for the CYP1A2 or ADORA2A genes in this group of Brazilian athletes.
Licença:	Nutrients - This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Fonte: https://www.mdpi.com/openaccess. Acesso em: 13 set. 2022.
DOI:	https://doi.org/10.3390/nu14163355
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