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Universidade de Brasília
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dc.contributor.authorSilva, Jairo Gomes da-
dc.contributor.authorMorais, Rafael Martins de-
dc.contributor.authorSilva, Izabel Cristina Rodrigues da-
dc.contributor.authorAdimy, Mostafa-
dc.contributor.authorMancera, Paulo Fernando de Arruda-
dc.date.accessioned2022-07-06T11:06:01Z-
dc.date.available2022-07-06T11:06:01Z-
dc.date.issued2020-
dc.identifier.citationSILVA, Jairo Gomes da et al. A mathematical model for treatment of papillary thyroid cancer using the allee effect. Journal of Biological Systems, v. 28, n. 3, p. 701-718, 2020. DOI: https://doi.org/10.1142/S0218339020500138.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/44113-
dc.language.isoAlemãopt_BR
dc.publisherWorld Scientificpt_BR
dc.rightsAcesso Restritopt_BR
dc.titleA mathematical model for treatment of papillary thyroid cancer using the allee effectpt_BR
dc.typeArtigopt_BR
dc.subject.keywordTireoide - tumorespt_BR
dc.subject.keywordInterleucina 6pt_BR
dc.subject.keywordRadioiodinapt_BR
dc.subject.keywordEquações diferenciais ordináriaspt_BR
dc.identifier.doihttps://doi.org/10.1142/S0218339020500138pt_BR
dc.description.abstract1The incidence of thyroid cancer is rising all over the world, and the papillary subtype (PTC) is the primary factor for this increase. The presence of thyroid tumors is commonly associated with increased levels of cytokines, such as interleukin 6 (IL-6). Considering PTC patients treated with thyroidectomy and radioactive iodine 131I (RAI), we propose an ordinary differential system using four variables: the RAI activity, the number of cancer cells and the serum concentrations of IL-6 and thyroglobulin (Tg). Our objective is to study the efficacy of different therapeutic doses of RAI in the treatment of thyroid cancer. The Allee effect is taken into account when modeling cancer cells growth under the influence of IL-6. From the results obtained, the main factors and conditions correlated with successful treatment, such as the RAI activity used and the tumor response are addressed. The detection of minimal doses of RAI that can cause tumor extinction is performed, though this has also meant longer periods for tumor cell elimination. The critical number of tumor cells due to the Allee effect is analyzed and linked to the immune system or biological factors that can slow the progression of the tumor but are insufficient after thyroid resection surgery.pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)-
dc.description.unidadeCurso de Saúde Coletiva (FCE-SC)-
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