Effectiveness of ozone therapy in the treatment of endometritis in mares

Ávila, Ana Caroline Araújo; Diniz, Natália Castro; Serpa, Rafael Torres; Chaves, Maria Manoela Barata de Castro; Viu, Marco Antônio de Oliveira; Oliveira, Rodrigo Arruda de

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Campo DC	Valor	Idioma
dc.contributor.author	Ávila, Ana Caroline Araújo	-
dc.contributor.author	Diniz, Natália Castro	-
dc.contributor.author	Serpa, Rafael Torres	-
dc.contributor.author	Chaves, Maria Manoela Barata de Castro	-
dc.contributor.author	Viu, Marco Antônio de Oliveira	-
dc.contributor.author	Oliveira, Rodrigo Arruda de	-
dc.date.accessioned	2022-05-13T13:28:02Z	-
dc.date.available	2022-05-13T13:28:02Z	-
dc.date.issued	2022	-
dc.identifier.citation	ÁVILA, Ana Caroline Araújo et al. Effectiveness of ozone therapy in the treatment of endometritis in mares. Journal of Equine Veterinary Science, v. 112, 103900, 2022. DOI: https://doi.org/10.1016/j.jevs.2022.103900. Disponível em: https://www.sciencedirect.com/science/article/pii/S0737080622000387. Acesso em: 13 maio 2022.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/43702	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Effectiveness of ozone therapy in the treatment of endometritis in mares	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Bactérias	pt_BR
dc.subject.keyword	Citologia	pt_BR
dc.subject.keyword	Cavalo	pt_BR
dc.subject.keyword	Ozônio	pt_BR
dc.subject.keyword	Útero - inflamação	pt_BR
dc.rights.license	© 2022 Elsevier Inc. All rights reserved.	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.jevs.2022.103900	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0737080622000387	pt_BR
dc.description.abstract1	Endometritis is defined as inflammation of the endometrium that may be acute or chronic, infectious, or non-infectious. Endometritis is an important cause of subfertility in mares. Considering the antimicrobial characteristics, immune-stimulating ability, and low cost of ozone (O3) therapy, we aimed to evaluate the effectiveness of intrauterine O3 therapy as an alternative treatment for endometritis in mares. Twenty-five mares with a known reproductive history of uterine infection and inflammation were allocated into three groups: Group 1 (control; n = 7), uterine lavage with Ringer's lactate solution; Group 2 (O3-gas; n = 9), uterine lavage with Ringer's lactate solution followed by uterine insufflation with O2-O3 gas mixture containing 40 µg O3 mL−1 for 10 minute; and Group 3 (O3-oil; n = 9), uterine infusion of ozonized sunflower oil. Uterine inflammation was evaluated through a uterine cytological examination (cytobrush) and uterine culture (swab) for microbiological content before and after all treatments. In assessments of uterine cytology, the average number of neutrophils/field changed from 9.14 ± 3.02 to 7.71 ± 3.59 in the control group, from 10.67 ± 3.84 to 2.89 ± 3.59 in the O3-gas group, and from 6.44 ± 2.79 to 6.55 ± 7.18 in the O3-oil group post-treatment. The pre- and post-treatment findings in the mares treated with ozonized gas were significantly different (P < .05), unlike the findings for the mares in the control and O3-oil groups. All mares (25/25) showed a positive uterine culture before treatment. After treatment, the percentage of mares showing positive culture results was 57%, 11%, and 22% in the control, O3-gas, and O3-oil groups, respectively. Our results showed the effectiveness of two groups (O2-O3 gas mixture and ozonized sunflower oil) for the treatment of uterine infections in mares. Thus, direct intrauterine O3 gas infusion has been shown to be effective in treating endometritis in mares, reducing both inflammation and uterine infection.	pt_BR
dc.description.unidade	Faculdade de Agronomia e Medicina Veterinária (FAV)	-
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