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dc.contributor.authorFerreira, Juliana de Freitas-
dc.contributor.authorMera López, Manuel Humberto-
dc.contributor.authorGomes, João Victor Dutra-
dc.contributor.authorMartins, Diegue Henrique Nascimento-
dc.contributor.authorFagg, Christopher William-
dc.contributor.authorBatista, Pérola de Oliveira Magalhães Dias-
dc.contributor.authorDavies, Noel William-
dc.contributor.authorSilveira, Dâmaris-
dc.contributor.authorBazzo, Yris Maria Fonseca-
dc.date.accessioned2022-05-05T15:04:26Z-
dc.date.available2022-05-05T15:04:26Z-
dc.date.issued2022-
dc.identifier.citationFERREIRA, Juliana de Freitas et al. Seasonal chemical evaluation of Miconia chamissois Naudin from Brazilian Savanna. Molecules, v. 27, n. 3, 1120, 2022. DOI: https://doi.org/10.3390/molecules27031120. Disponível em: https://www.mdpi.com/1420-3049/27/3/1120. Acesso em: 5 maio 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/43650-
dc.language.isoInglêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSeasonal chemical evaluation of Miconia chamissois Naudin from Brazilian Savannapt_BR
dc.typeArtigopt_BR
dc.subject.keywordMiconia chamissoispt_BR
dc.subject.keywordSazonalidadept_BR
dc.subject.keywordCerradospt_BR
dc.rights.license(CC BY)pt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules27031120pt_BR
dc.description.abstract1Miconia chamissois Naudin is a species from the Cerrado, which is being increasingly researched for its therapeutic potential. The aim of this study was to obtain a standardized extract and to evaluate seasonal chemical variations. Seven batches of aqueous extracts from leaves were produced for the standardization. These extracts were evaluated for total solids, polyphenol (TPC) and flavonoid content (TFC), vitexin derivative content, antioxidant activity; thin-layer chromatography (TLC), and high-performance liquid chromatography (HPLC) profiles were generated. For the seasonal study, leaves were collected from five different periods (May 2017 to August 2018). The results were correlated with meteorological data (global radiation, temperature, and rainfall index). Using chromatographic and spectroscopic techniques, apigenin C-glycosides (vitexin/isovitexin) and derivatives, luteolin C-glycosides (orientin/isoorientin) and derivatives, a quercetin glycoside, miconioside B, matteucinol-7-O-β-apiofuranosyl (1 → 6) -β-glucopyranoside, and farrerol were identified. Quality parameters, including chemical marker quantification by HPLC, and biological activity, are described. In the extract standardization process, all the evaluated parameters showed low variability. The seasonality study revealed no significant correlations (p < 0.05) between TPC or TFC content and meteorological data. These results showed that it is possible to obtain extracts from M. chamissois at any time of the year without significant differences in composition.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8727-0043pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6098-3852pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6072-7832pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8011-6940pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1851-5224pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1230-3207pt_BR
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