Título:	Exposure to endocrine disruptors and risk of breast cancer : a systematic review
Autor(es):	Rocha, Priscilla Roberta Silva Oliveira, Valdiane Dutra Vasques, Christiane Inocêncio Reis, Paula Elaine Diniz dos Amato, Angélica Amorim
Assunto:	Mamas - câncer Sistema endócrino Exposição ambiental Toxicidade Desreguladores endócrinos
Data de publicação:	Mai-2021
Editora:	Elsevier
Referência:	ROCHA, Priscilla Roberta Silva et al. Exposure to endocrine disruptors and risk of breast cancer: a systematic review. Critical Reviews in Oncology/Hematology, v. 161, 103330, maio 2021. DOI: https://doi.org/10.1016/j.critrevonc.2021.103330. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S1040842821001189. Acesso em: 12 fev. 2022.
Abstract:	Aim The aim of this study was to investigate the association between human exposure to endocrine disruptors (EDs) and the risk of breast cancer. Methods This was a systematic review conducted by searching Cochrane Library, LILACS, Livivo, PubMed, and Science Direct. Observational studies addressing the association between exposure to EDs and breast cancer risk in adults were included. Risk of bias was assessed using the National Toxicology Program’s Office of Health Assessment Translation tool. Results a total of 37 studies were included. Most studies reported that exposure to organochlorine pesticides, phthalates, heavy metals, and polycyclic aromatic hydrocarbons was associated with increased breast cancer risk. Conclusion qualitative analysis of observational studies indicates that human exposure to EDs is associated with increased breast cancer risk. Additional studies are needed to determine whether this association is causal.
Unidade Acadêmica:	Faculdade UnB Ceilândia (FCE) Curso de Enfermagem (FCE-ENF)
Licença:	© 2021 Elsevier B.V. All rights reserved.
DOI:	https://doi.org/10.1016/j.critrevonc.2021.103330
Versão da editora:	https://www.sciencedirect.com/science/article/abs/pii/S1040842821001189
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