The association between excess body weight at diagnosis and pediatric leukemia prognosis : a systematic review and meta-analysis

Galati, Paula Cristina; Ribeiro, Carolina Martins; Pereira, Louise Tavares Garcia; Amato, Angélica Amorim

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Élément Dublin Core	Valeur	Langue
dc.contributor.author	Galati, Paula Cristina	-
dc.contributor.author	Ribeiro, Carolina Martins	-
dc.contributor.author	Pereira, Louise Tavares Garcia	-
dc.contributor.author	Amato, Angélica Amorim	-
dc.date.accessioned	2022-02-12T02:24:57Z	-
dc.date.available	2022-02-12T02:24:57Z	-
dc.date.issued	2022-01	-
dc.identifier.citation	GALATI, Paula Cristina et al. The association between excess body weight at diagnosis and pediatric leukemia prognosis: a systematic review and meta-analysis. Blood Reviews, v. 51, 100870, jan. 2022. DOI: https://doi.org/10.1016/j.blre.2021.100870. Disponível em: https://www.sciencedirect.com/science/article/pii/S0268960X2100076X. Acesso em: 11 fev. 2022.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/42867	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	The association between excess body weight at diagnosis and pediatric leukemia prognosis : a systematic review and meta-analysis	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Leucemia pediátrica	pt_BR
dc.subject.keyword	Mortalidade	pt_BR
dc.subject.keyword	Sobrevivência	pt_BR
dc.subject.keyword	Sobrepeso	pt_BR
dc.subject.keyword	Obesidade	pt_BR
dc.rights.license	© 2021 Elsevier Ltd. All rights reserved.	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.blre.2021.100870	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0268960X2100076X	pt_BR
dc.description.abstract1	Obesity affects the prognosis of several types of cancer. However, whether excess body weight is independently associated with adverse outcomes following initial pediatric acute leukemia (AL) treatment is still unclear. We conducted a systematic review and meta-analysis to investigate the impact of overweight/obesity at diagnosis on pediatric AL prognosis following initial treatment by performing an extensive database search up to January 22, 2021. Twenty-three studies were included, providing data for 15689 children with acute lymphoblastic leukemia (ALL) and 2506 children with acute myeloid leukemia (AML). Data from 12 studies were pooled in the meta-analysis. Children with overweight/obesity at diagnosis of ALL had poorer event free-survival (random-effects hazard ratio of 1.44, 95%CI 1.16–1.79, p = 0.0008), but no difference in overall survival (random-effects hazard ratio 1.33, 95%CI 0.77–2.29, p = 0.31) when compared with healthy-weight children. Children with overweight/obesity at diagnosis of AML had no difference in event-free survival (random-effects hazard ratio of 0.88, 95%CI 0.48–1.59, p = 0.66) or overall survival (random-effects hazard ratio 1.40, 95%CI 0.78–2.49, p = 0.26), when compared with healthy-weight children. This systematic review and meta-analysis indicates that overweight/obesity negatively affects the prognosis of children with ALL. Future studies should address the best approach to consider nutritional status in their management.	pt_BR
Collection(s) :	Artigos publicados em periódicos e afins