Título:	Depression and frailty in older adults : a population-based cohort study
Autor(es):	Mata, Fabiana Araújo Figueiredo da Gomes, Marilia Miranda Forte Santos, Jair Lício Ferreira Duarte, Yeda Aparecida de Oliveira Pereira, Mauricio Gomes
ORCID:	https://orcid.org/ 0000-0003-3762-9091 https://orcid.org/ 0000-0001-7367-4418
Assunto:	Adultos Idosos Depressão mental Fragilidade
Data de publicação:	4-Mar-2021
Editora:	Plos One
Referência:	MATA, Fabiana Araújo Figueiredo da et al. Depression and frailty in older adults: a population-based cohort study. PLoS ONE, v. 16, n. 3, e0247766, 2021. DOI: https://doi.org/10.1371/journal.pone.0247766. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0247766. Acesso em: 02 dez. 2021.
Abstract:	Background Studies have shown an association between depression and frailty, even though the literature has not reached a consensus regarding how these syndromes interact. Although prospective cohort studies on this topic are still scarce, they could contribute to understanding this relationship. We aimed to observe whether depressive symptoms are risk factors for the onset of frailty among older adults living in São Paulo, Brazil. Methods Prospective cohort study using the “Health, Well-being and Aging” (SABE) Study databases of 2006 and 2010. The sample was representative of the community-dwelling older adults living in São Paulo, and it is composed of non-frail men and women aged 60 years and older without cognitive decline. We calculated the frailty incidence rate between older adults with and without depressive symptoms and calculated the incidence rate ratio. Multiple analysis was carried out through Poisson regression with robust variance estimation. Results The initial sample (n = 1,109) presented a mean age of 72 years (from 60 to 96) and 61.1% were women. The final sample was composed of 830 individuals, and the mean follow-up time in the study was 3.8 years. After adjusting the model, depressive symptoms did not predict the onset of frailty at follow-up. Conclusion Depressive symptoms were not shown to be a risk factor for frailty among older adults living in São Paulo in this study.
Unidade Acadêmica:	Faculdade UnB Gama (FGA)
Licença:	Copyright: © 2021 Da Mata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/10.1371/journal.pone.0247766
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