| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Oliveira, Jade de | - |
| dc.contributor.author | Engel, Daiane F. | - |
| dc.contributor.author | Paula, Gabriela C. de | - |
| dc.contributor.author | Santos, Danubia B. dos | - |
| dc.contributor.author | Lopes, Jadna B. | - |
| dc.contributor.author | Farina, Marcelo | - |
| dc.contributor.author | Moreira, Eduardo L. G. | - |
| dc.contributor.author | Bem, Andreza Fabro de | - |
| dc.date.accessioned | 2021-10-14T12:45:36Z | - |
| dc.date.available | 2021-10-14T12:45:36Z | - |
| dc.date.issued | 2020-10-27 | - |
| dc.identifier.citation | OLIVEIRA, Jade de et al. High cholesterol diet exacerbates blood-brain barrier disruption in LDLr–/– mice: impact on cognitive function. Journal of Alzheimer's Disease, v. 78, n. 1, p. 97-115, 2020. DOI: 10.3233/JAD-200541. Disponível em: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad200541. Acesso em: 14 out. 2021. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/42136 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | IOS Press | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | High cholesterol diet exacerbates blood-brain barrier disruption in LDLr–/– mice : impact on cognitive function | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Barreira hemencefálica | pt_BR |
| dc.subject.keyword | Hipercolesterolemia familiar | pt_BR |
| dc.subject.keyword | Camundongos | pt_BR |
| dc.subject.keyword | Memória | pt_BR |
| dc.subject.keyword | Prejuízo cognitivo leve | pt_BR |
| dc.subject.keyword | Neuroinflamação | pt_BR |
| dc.rights.license | © 2020 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). | pt_BR |
| dc.identifier.doi | 10.3233/JAD-200541 | pt_BR |
| dc.description.abstract1 | Background: Evidence has revealed an association between familial hypercholesterolemia and cognitive impairment. In
this regard, a connection between cognitive deficits and hippocampal blood-brain barrier (BBB) breakdown was found in
low-density lipoprotein receptor knockout mice (LDLr–/–), a mouse model of familial hypercholesterolemia.
Objective: Herein we investigated the impact of a hypercholesterolemic diet on cognition and BBB function in C57BL/6
wild-type and LDLr–/– mice.
Methods: Animals were fed with normal or high cholesterol diets for 30 days. Thus, wild-type and LDLr–/– mice were
submitted to memory paradigms. Additionally, BBB integrity was evaluated in the mice’s prefrontal cortices and hippocampi.
Results: A tenfold elevation in plasma cholesterol levels of LDLr–/– mice was observed after a hypercholesterolemic diet,
while in wild-type mice, the hypercholesterolemic diet exposure increased plasma cholesterol levels only moderately and
did not induce cognitive impairment. LDLr–/– mice presented memory impairment regardless of the diet. We observed BBB
disruption as an increased permeability to sodium fluorescein in the prefrontal cortices and hippocampi and a decrease on
hippocampal claudin-5 and occludin mRNA levels in both wild-type and LDLr–/– mice treated with a hypercholesterolemic
diet. The LDLr–/– mice fed with a regular diet already presented BBB dysfunction. The BBB-increased leakage in the
hippocampi of LDLr–/– mice was related to high microvessel content and intense astrogliosis, which did not occur in the
control mice.
Conclusion: Therefore, LDLr–/– mice seem to be more susceptible to cognitive impairments and BBB damage induced by
exposure to a high cholesterol diet. Finally, BBB disruption appears to be a relevant event in hypercholesterolemia-induced
brain alterations. | pt_BR |
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