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dc.contributor.authorMnafgui, Kais-
dc.contributor.authorGhazouani, Lakhdar-
dc.contributor.authorHajji, Raouf-
dc.contributor.authorTlili, Abir-
dc.contributor.authorDerbali, Fatma-
dc.contributor.authorSilva, Francisco Ivan da-
dc.contributor.authorAraújo, Joabe Lima-
dc.contributor.authorSchinoff, Bianca de Oliveira-
dc.contributor.authorBachega, José Fernando Ruggiero-
dc.contributor.authorSantos, Antônia Laíres da Silva-
dc.contributor.authorAllouche, Noureddine-
dc.date.accessioned2021-06-01T16:34:07Z-
dc.date.available2021-06-01T16:34:07Z-
dc.date.issued2021-05-18-
dc.identifier.citationMNAFGUI, Kais et al. Oleuropein protects against cerebral ischemia injury in rats: molecular docking, biochemical and histological findings. Neurochemical Research, 2021. DOI: https://doi.org/10.1007/s11064-021-03351-9.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/41075-
dc.language.isoInglêspt_BR
dc.publisherSpringerpt_BR
dc.rightsAcesso Restritopt_BR
dc.titleOleuropein protects against cerebral ischemia injury in rats : molecular docking, biochemical and histological findingspt_BR
dc.typeArtigopt_BR
dc.subject.keywordOleuropeínapt_BR
dc.subject.keywordIsomerase de dissulfeto de proteínapt_BR
dc.subject.keywordStress oxidativopt_BR
dc.identifier.doihttps://doi.org/10.1007/s11064-021-03351-9pt_BR
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s11064-021-03351-9pt_BR
dc.description.abstract1This study was designed to evaluate the underlying protective mechanisms of oleuropein involved in alleviating brain damage in a rat model of ischemic stroke. Male Wistar rats were divided into four groups; Control, stroke (MCAO), MCAO + clopidogrel (Clop) and MCAO + oleuropein (Ole). Results showed that the MCAO group evidenced significant brain edema (+ 9%) as well as increases of plasma cardiac markers such as lactate deshydrogenase (LDH), creatine kinase (CK-MB), fibrinogen and Trop-T by 11 %, 43%, 168 and 590%, respectively, as compared to the control group. Moreover, infarcted rats exhibited remarkable elevated levels of angiotensin converting enzyme (ACE), both in plasma and brain tissue, with astrocyte swelling and necrotic neurons in the infarct zone, hyponatremia, and increased rate of thiobarbituric acid-reactive substances (TBARS) by 89% associated with decreases in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (Cat) by 51%, 44 and 42%, respectively, compared to normal control rats. However, MCAO rats treated with oleuropein underwent mitigation of cerebral edema, correction of hyponatremia, remarkable decrease of plasma fibrinogen and cardiac dysfunctional enzymes, inhibition of ACE activity and improvement of oxidative stress status in brain tissue. Furthermore, in silico analysis showed considerable inhibitions of ACE, protein disulfide isomerase (PDI) and TGF-β1, an indicative of potent anti-embolic properties. Overall, oleuropein offers a neuroprotective effect against ischemic stroke through its antioxidative and antithrombotic activities.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9551-6266pt_BR
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