Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique

Santos, Gabriella Sousa; Sinoti, Simone Batista Pires; Almeida, Fabrício Tavares Cunha de; Silveira, Dâmaris; Simeoni, Luiz Alberto; Gomes-Copeland, Kicia Karinne Pereira

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Campo DC	Valor	Idioma
dc.contributor.author	Santos, Gabriella Sousa	-
dc.contributor.author	Sinoti, Simone Batista Pires	-
dc.contributor.author	Almeida, Fabrício Tavares Cunha de	-
dc.contributor.author	Silveira, Dâmaris	-
dc.contributor.author	Simeoni, Luiz Alberto	-
dc.contributor.author	Gomes-Copeland, Kicia Karinne Pereira	-
dc.date.accessioned	2021-05-26T15:02:51Z	-
dc.date.available	2021-05-26T15:02:51Z	-
dc.date.issued	2020	-
dc.identifier.citation	Santos, Gabriella Sousa et al. Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique. Plant Cell Tiss Organ Cult, v. 143, p. 13-29, 2020. DOI: https://doi.org/10.1007/s11240-020-01911-5.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/41040	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Springer Nature	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Alzheimer, Doença de	pt_BR
dc.subject.keyword	Amaryllidaceae	pt_BR
dc.subject.keyword	Biossíntese	pt_BR
dc.subject.keyword	Medicamentos	pt_BR
dc.subject.keyword	Cultivo in vitro	pt_BR
dc.identifier.doi	https://doi.org/10.1007/s11240-020-01911-5	pt_BR
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s11240-020-01911-5	pt_BR
dc.description.abstract1	Galantamine is an alkaloid in the Amaryllidaceae family widely used in the treatment of Alzheimer's disease. Since its approval for clinical use in 2001, its effectiveness has been attested in numerous clinical trials. Due to the expressive and growing increase in Alzheimer's disease cases in the world, driven by the increase in life expectancy, the main risk factor for neurodegenerative diseases, demand for galantamine is expected to be intensified, this aggravating factor has encouraged researchers to seek viable alternatives for the commercialization of galantamine on a larger scale. However, due to its complex stereochemistry, the organic synthesis of galantamine proved to be a challenging task, thus constituting plants as its main source of production. In this sense, biotechnological techniques have emerged as an alternative and a more efficient means, since plants biosynthesize galantamine and other alkaloids without difficulty. This review summarizes the results of studies on the tools currently available in plant tissue culture capable of optimizing galantamine production aiming at large scale production for the treatment of Alzheimer's disease. Results of galantamine biosynthesis optimization from the use of biotic and abiotic elicitors, plants growth regulators, phytoregulator and precursors agents or intermediate components, endorse the clinical importance of galantamine in the treatment of Alzheimer's disease and the role of in vitro cultivation technique as an environmentally sustainable culture, are discussed.	pt_BR
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