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dc.contributor.authorMorais Júnior, Gilberto Santos-
dc.contributor.authorKurizky, Patricia Shu-
dc.contributor.authorCerqueira, Selma Regina Penha Silva-
dc.contributor.authorBarroso, Daniel Holanda-
dc.contributor.authorSchulte, Heidi Luise-
dc.contributor.authorAlbuquerque, Cleandro Pires de-
dc.contributor.authorGois, Eliana Teles de-
dc.contributor.authorEspindola, Laila Salmen-
dc.contributor.authorSantana, Jaime Martins de-
dc.contributor.authorBastos, Izabela Marques Dourado-
dc.contributor.authorAraújo, Carla Nunes de-
dc.contributor.authorMota, Licia Maria Henrique da-
dc.contributor.authorNóbrega, Otávio de Tolêdo-
dc.contributor.authorGomes, Ciro Martins-
dc.date.accessioned2021-05-12T11:25:02Z-
dc.date.available2021-05-12T11:25:02Z-
dc.date.issued2021-
dc.identifier.citationMORAIS JUNIOR, Gilberto Santos et al. Enhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damage. The American Journal of Tropical Medicine and Hygiene, Ahead of Print, p. 1-5, 2021. DOI: https://doi.org/10.4269/ajtmh.21-0034. Disponível em: https://www.ajtmh.org/view/journals/tpmd/aop/article-10.4269-ajtmh.21-0034/article-10.4269-ajtmh.21-0034.xml. Acesso em: 03 maio 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/40909-
dc.language.isoInglêspt_BR
dc.publisherAmerican Society of Tropical Medicine and Hygienept_BR
dc.relation.isbasedonhttps://repositorio.unb.br/handle/10482/41534-
dc.rightsAcesso Abertopt_BR
dc.titleEnhanced il-6 and il-12b gene expression after SARS-CoV-2 infection in leprosy patients may increase the risk of neural damagept_BR
dc.typeArtigopt_BR
dc.subject.keywordHanseníasept_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordCovid-19pt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - (CC BY NC). Fonte: https://www.ajtmh.org/view/journals/tpmd/aop/article-10.4269-ajtmh.21-0034/article-10.4269-ajtmh.21-0034.xml. Acesso em: 04 maio 2021.pt_BR
dc.identifier.doihttps://doi.org/10.4269/ajtmh.21-0034pt_BR
dc.description.abstract1Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)–related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. We included 64 leprosy patients and 50 controls. Twelve of the leprosy patients and 14 of the controls had been diagnosed with COVID-19. Co-infection was associated with increased IL-6 (P = 0.043) and IL-12B (P = 0.017) expression. The median disability grades were higher for leprosy/COVID-19 patients; however, the difference was not significant (P = 0.194). Patients co-infected with M. leprae and SARS-CoV-2 may experience a higher-grade proinflammatory state.pt_BR
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