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Universidade de Brasília
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/39924
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dc.contributor.authorLoyola, Mariana Braccialli de-
dc.contributor.authorReis, Thaís Tereza Aguiar dos-
dc.contributor.authorOliveira, Guilherme Xavier Lyra Malcher de-
dc.contributor.authorPalmeira, Julys da Fonseca-
dc.contributor.authorArgañaraz, Gustavo Adolfo-
dc.contributor.authorArgañaraz, Enrique Roberto-
dc.date.accessioned2021-01-18T13:39:23Z-
dc.date.available2021-01-18T13:39:23Z-
dc.date.issued2020-08-26-
dc.identifier.citationLOYOLA, Mariana Braccialli de et al. Alpha‐1‐antitrypsin: a possible host protective factor against Covid‐19. Reviews in Medical Virology, e2157, 2020. DOI: https://doi.org/10.1002/rmv.2157. Disponível em: https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2157.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/39924-
dc.language.isoInglêspt_BR
dc.publisherWileypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleAlpha‐1‐antitrypsin : a possible host protective factor against Covid‐19pt_BR
dc.typeArtigopt_BR
dc.subject.keywordA1ATpt_BR
dc.subject.keywordADAM17pt_BR
dc.subject.keywordCovid-19pt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordTMPRSS2pt_BR
dc.identifier.doihttps://doi.org/10.1002/rmv.2157pt_BR
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2157pt_BR
dc.description.abstract1Understanding Covid‐19 pathophysiology is crucial for a better understanding of the disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a constitutive tissue protector with antiviral and anti‐inflammatory properties. A1AT inhibits SARS‐CoV‐2 infection and two of the most important proteases in the pathophysiology of Covid‐19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17). It also inhibits the activity of inflammatory molecules, such as IL‐8, TNF‐α, and neutrophil elastase (NE). TMPRSS2 is essential for SARS‐CoV‐2‐S protein priming and viral infection. ADAM17 mediates ACE2, IL‐6R, and TNF‐α shedding. ACE2 is the SARS‐CoV‐2 entry receptor and a key component for the balance of the renin‐angiotensin system, inflammation, vascular permeability, and pulmonary homeostasis. In addition, clinical findings indicate that A1AT levels might be important in defining Covid‐19 outcomes, potentially partially explaining associations with air pollution and with diabetes. In this review, we focused on the interplay between A1AT with TMPRSS2, ADAM17 and immune molecules, and the role of A1AT in the pathophysiology of Covid‐19, opening new avenues for investigating effective treatments.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7816-764Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4359-7594pt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins
UnB - Covid-19

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