| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Ribeiro, Carolina Martins | - |
| dc.contributor.author | Beserra, Bruna Teles Soares | - |
| dc.contributor.author | Silva, Nadyellem Graciano | - |
| dc.contributor.author | Lima, Caroline Lourenço | - |
| dc.contributor.author | Rocha, Priscilla Roberta Silva | - |
| dc.contributor.author | Coelho, Michella Soares | - |
| dc.contributor.author | Neves, Francisco de Assis Rocha | - |
| dc.contributor.author | Amato, Angélica Amorim | - |
| dc.date.accessioned | 2020-06-26T19:53:15Z | - |
| dc.date.available | 2020-06-26T19:53:15Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.citation | RIBEIRO, Carolina Martins et al. Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity: a systematic review and meta-analysis. BMJ Open, v. 10, n. 6, e033509, 2020. DOI: http://dx.doi.org/10.1136/bmjopen-2019-033509. Disponível em: https://bmjopen.bmj.com/content/10/6/e033509. Acesso em: 26 jun. 2020. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/38303 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | BMJ Open | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity : a systematic review and meta-analysis | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Produtos químicos | pt_BR |
| dc.subject.keyword | Sistema endócrino | pt_BR |
| dc.subject.keyword | Obesidade | pt_BR |
| dc.rights.license | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | pt_BR |
| dc.identifier.doi | http://dx.doi.org/10.1136/bmjopen-2019-033509 | pt_BR |
| dc.description.abstract1 | Objective Endocrine-disrupting chemicals (EDCs) are viewed as a major potential link between the environment
and obesity development. We did a systematic review and meta-analysis to examine the association between
exposure to EDCs and obesity. Data sources, design and eligibility criteria PubMed, Scopus and Web of Science were searched from inception to 6 June 2018 for studies primarily addressing the association between exposure to EDCs after the age of 2
years and anthropometric measures of obesity or body fat. The Newcastle-Ottawa scale was used to assess the risk
of bias. Data extraction and synthesis Two independent reviewers screened and conducted data extraction and
synthesis. A third reviewer resolved disagreements. Results A total of 73 studies investigating bisphenol
A (32 286 individuals), organochlorine compounds (34 567 individuals), phthalates (21 401 individuals),
polybrominated biphenyls (2937 individuals), polycyclic aromatic hydrocarbons (5174 individuals), parabens
(4097 individuals), benzoic acid (3671 individuals) and polyfluoroalkyl substances (349 individuals) met our
inclusion criteria. Most had a cross-sectional design and low or medium risk of bias. In qualitative analysis,
bisphenol A and phthalates were consistently associated with general and abdominal obesity, in children and
adults, and some studies suggested this association was age-dependent and gender-dependent. Meta-analysis
indicated a significant association between exposure to bisphenol A and overweight (OR 1.254, 95%CI 1.005
to 1.564), obesity (OR 1.503, 95%CI 1.273 to 1.774) and increased waist circumference (OR 1.503, 95%CI
1.267 to 1.783) in adults, and between exposure to 2,5-dichlorophenol and obesity in children (OR 1.8,
95%CI 1.1018 to 3.184). Conclusion Most observational studies supported a positive association between obesity and exposure to EDCs. Although causality cannot be determined from these data, they underscore the need to limit human exposure
to EDCs in light of the evidence from animal and cellbased studies indicating the effects of these chemicals on adiposity. | pt_BR |
| dc.identifier.orcid | http://orcid.org/0000-0002-8454-5504 | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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