Sex differences in blood pressure regulation during ischemic isometric exercise : the role of the β-adrenergic receptors

Samora, Milena; Incognito, Anthony V.; Vianna, Lauro Casqueiro

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Campo DC	Valor	Idioma
dc.contributor.author	Samora, Milena	-
dc.contributor.author	Incognito, Anthony V.	-
dc.contributor.author	Vianna, Lauro Casqueiro	-
dc.date.accessioned	2020-06-09T12:57:27Z	-
dc.date.available	2020-06-09T12:57:27Z	-
dc.date.issued	2019-08-10	-
dc.identifier.citation	SAMORA, Milena; INCOGNITO, Anthony V.; VIANNA, Lauro C. Sex differences in blood pressure regulation during ischemic isometric exercise: the role of the β-adrenergic receptors. Journal of Applied Physiology, v. 127, p. 408-414, 2019. DOI: https://doi.org/10.1152/japplphysiol.00270.2019. Disponível em: https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00270.2019.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/38005	-
dc.language.iso	Inglês	pt_BR
dc.publisher	American Physiological Society	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Sex differences in blood pressure regulation during ischemic isometric exercise : the role of the β-adrenergic receptors	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Pressão arterial	pt_BR
dc.subject.keyword	Exercícios físicos	pt_BR
dc.identifier.doi	https://doi.org/10.1152/japplphysiol.00270.2019	pt_BR
dc.relation.publisherversion	https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00270.2019	pt_BR
dc.description.abstract1	We sought to investigate whether the β-adrenergic receptors play a pivotal role in sex-related differences in arterial blood pressure (BP) regulation during isometric exercise. Sixteen volunteers (8 women) performed 2 min of ischemic isometric handgrip exercise (IHE) and 2 min of postexercise circulatory occlusion (PECO). Heart rate (HR) and beat-to-beat arterial BP were continuously measured. Beat-to-beat estimates of stroke volume (ModelFlow) were obtained and matched with HR to calculate cardiac output (Q̇) and total peripheral resistance (TPR). Two trials were randomly conducted between placebo and nonselective β-adrenergic blockade (40 mg propranolol). Under the placebo condition, the magnitude of the BP response in IHE was lower in women compared with men. During PECO, the BP remained elevated and the sex differences persisted. The β-blockade attenuated the BP response during IHE in men (∆57 ± 4 vs. ∆45 ± 7 mmHg, P = 0.025) due to a reduction in Q̇ (∆3.7 ± 0.5 vs. ∆1.8 ± 0.2 L/min, P = 0.012) while TPR was not affected. In women, however, the BP response during IHE was unchanged (∆27 ± 3 vs. ∆28 ± 3 mmHg, P = 0.889), despite attenuated Q̇ (∆2.7 ± 0.4 vs. ∆1.3 ± 0.2 L/min, P = 0.012). These responses were mediated by a robust increase in TPR under β-blockade (∆−0.2 ± 0.4 vs. ∆2.2 ± 0.7 mmHg·L−1·min, P = 0.012). These findings demonstrate that the sex differences in arterial BP regulation during ischemic IHE are mediated by β-adrenergic receptors.	pt_BR
dc.description.unidade	Faculdade de Educação Física (FEF)	-
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