Skip navigation
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/37258
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_EvidenceContributionAPOE.pdf185,2 kBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorCamargos, Einstein Francisco de-
dc.contributor.authorGoncalves, Isabela D.-
dc.contributor.authorBretones, Luiza Alvarenga Lima-
dc.contributor.authorMachado, Marcela F. M.-
dc.contributor.authorMorais Júnior, Gilberto Santos-
dc.contributor.authorBrito, Artur Felipe Siqueira de-
dc.contributor.authorHenriques, Adriane Dallanora-
dc.contributor.authorMorais, Clayton Franco-
dc.contributor.authorNóbrega, Otávio de Tolêdo-
dc.date.accessioned2020-03-31T15:56:44Z-
dc.date.available2020-03-31T15:56:44Z-
dc.date.issued2019-
dc.identifier.citationCAMARGOS, Einstein F. et al. Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults. International Journal of Molecular Epidemiology and Genetics, Madison, v. 10, n. 4, p. 59-66, 2019. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737399/. Acesso em: 30 mar. 2020.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/37258-
dc.language.isoInglêspt_BR
dc.publishere-Century Publishing Corporationpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEvidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adultspt_BR
dc.typeArtigopt_BR
dc.subject.keywordApolipoproteínapt_BR
dc.subject.keywordGenotipagempt_BR
dc.subject.keywordSonopt_BR
dc.subject.keywordIdosospt_BR
dc.subject.keywordCognição - idosospt_BR
dc.rights.licenseInternational Journal of Molecular Epidemiology and Genetics - Copyright Policy - Once the paper is published, the copyright will be released by the publisher under the “Creative Commons Attribution Noncommercial License”, enabling the unrestricted non-commercial use, distribution, and reproduction of the published article in any medium, provided that the original work is properly cited. Fonte: http://ijmeg.org/ForAuthors.html. Acesso em: 30 mar. 2020.pt_BR
dc.description.abstract1This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors for poor quality of sleep in elderly individuals with no major cognitive decline. This cross-sectional, analytical study was conducted with 163 participants aged 75 years in average and 85% female. Sociodemographic, anthropometric and clinical data were gathered, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth scale, with patient followed for years prior to these evaluations to rule out onset of major mental disorders. Genotyping of classic polymorphic sites for the ApoE (rs429358 and rs7412) and the ACE (rs4646994) genes used peripheral DNA. A total of 63% of the subjects reported poor quality of sleep assessed by the PSQI whereas 54 (33%) reported daytime sleepiness through the Epworth scale. A significant correlation was observed between APOE and PSQI, with a greater frequency of the poor nighttime sleep quality phenotype among ε2 carriers, whereas no correlation was found among any of the sleep scores and the ACE genotypes. Thus, we suggest a correlation between APOE alleles and scale-assessed sleep quality scores in older adults, with no implications for ACE alleles, in a context devoid of cognitive impairment.pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.