| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Nóbrega, Yanna Karla de Medeiros | - |
| dc.date.accessioned | 2020-02-18T17:21:16Z | - |
| dc.date.available | 2020-02-18T17:21:16Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.citation | NÓBREGA, Yanna Karla de Medeiros. Genotype DQ2.5/DQ2.2 (𝛽2/𝛽2) and high celiac disease risk development. In: RODRIGO, Luis; HERNÁNDEZ-LAHOZ, Carlos (ed.). Celiac disease: from the bench to the clinic. Londres: IntechOpen, 2018. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/36925 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | IntechOpen | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Genotype DQ2.5/DQ2.2 (𝛽2/𝛽2) and high celiac disease risk development | pt_BR |
| dc.type | Parte de livro ou capítulo de livro | pt_BR |
| dc.subject.keyword | Doença celíaca | pt_BR |
| dc.subject.keyword | Fatores de risco | pt_BR |
| dc.rights.license | © 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY) | pt_BR |
| dc.description.abstract1 | Celiac disease (CD) is a genetically determined immune-mediated disorder in
which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5,
DQ8, DQ2.2, and their combinations. CD is considered one of the most wellcharacterized
autoimmune diseases, having a described environmental factor, a
well-established pathogenesis, associated genetic factors, and a well-established
laboratory diagnosis, although it is still considered a difficult-to-classify disease. In
the last decades, advances in laboratory diagnosis with the emergence of molecular
biology techniques have allowed a specific characterization of the CD-associated
genotypes and, although clinically the disease management was not modified
by this factor, the follow-up of patients at risk of CD development has greatly
benefited from the possibility of specifically finding the inherited genotype, and
whether it represents a greater or lesser risk for developing the disease. In some
populations, it is already possible to calculate the exact risk associated to the
inherited genome by each individual, but the genotypes available in several countries
sometimes disregard the relevance of searching beyond the genotypes DQ2.5/
DQ2.5, DQ2.5/DQ8, and DQ2.5/DQ2.2, which also present a high risk for developing
the disease. | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Farmácia (FS FAR) | pt_BR |
| Aparece nas coleções: | Livros e afins
|
