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dc.contributor.authorPinto, Raquel de Medeirospt_BR
dc.contributor.authorSampaio, Vanderson de Souzapt_BR
dc.contributor.authorMelo, Gisely Cardoso dept_BR
dc.contributor.authorAlecrim, Maria das Graças Costapt_BR
dc.contributor.authorMattos, Karinept_BR
dc.contributor.authorPerdomo, Renata Trentinpt_BR
dc.contributor.authorCordeiro, Sabrine da Costapt_BR
dc.contributor.authorParente, Ana Flávia Alvespt_BR
dc.contributor.authorCarvalho, Lídia Raquel dept_BR
dc.contributor.authorMendes, Rinaldo Pônciopt_BR
dc.contributor.authorLacerda, Marcus Vinícius Guimarães dept_BR
dc.contributor.authorMonteiro, Wuelton Marcelopt_BR
dc.contributor.authorWeber, Simone Schneiderpt_BR
dc.date.accessioned2020-01-24T10:30:01Z-
dc.date.available2020-01-24T10:30:01Z-
dc.date.issued2019pt_BR
dc.identifier.citationPINTO, Raquel de Medeiros et al. Overview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazon. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, e190075, 2019. DOI: https://doi.org/10.1590/0074-02760190075. Disponível em: http://scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100320. Acesso em: 23 jan. 2020.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/36257-
dc.language.isoenpt_BR
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúdept_BR
dc.rightsAcesso Abertopt_BR
dc.titleOverview of artemisinin effectiveness during outset years of its implementation in the western Brazilian Amazonpt_BR
dc.typeArtigopt_BR
dc.subject.keywordPlasmodium falciparumpt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordMalária - tratamentopt_BR
dc.subject.keywordEstudos de coortept_BR
dc.subject.keywordMalária-
dc.rights.license(CC BY)-
dc.identifier.doihttps://doi.org/10.1590/0074-02760190075pt_BR
dc.description.abstract1BACKGROUND The elimination of malaria depends on the blocking of transmission and of an effective treatment. In Brazil, artemisinin therapy was introduced in 1991, and here we present a performance overview during implementation outset years. METHODS It is a retrospective cohort (1991 to 2002) of patients treated in a tertiary centre of Manaus, with positive microscopic diagnosis of Plasmodium falciparum malaria, under treatment with using injectable or rectal artemisinin derivatives, and followed over 35-days to evaluate parasite clearance, death and recurrence. FINDINGS This cohort outcome resulted 97.6% (1554/1593) of patients who completed the 35-day follow-up, 0.6% (10/1593) of death and 1.8% (29/1593) of follow-up loss. All patients that died and those that presented parasitaemia recurrence had pure P. falciparum infections and received monotherapy. Considering patients who completed 35-day treatment, 98.2% (1527/1554) presented asexual parasitaemia clearance until D4 and 1.8% (27/1554) between D5-D10. It is important to highlight that had no correlation between the five treatment schemes and the sexual parasite clearance. Finally, it is noteworthy that we were able to observe also gametocytes carriage during all follow-up (D0-D35). MAIN CONCLUSIONS Artemisinin derivatives remained effective in the treatment of falciparum malaria during first 12-years of use in north area of Brazil.-
dc.identifier.orcidhttp://orcid.org/0000-0002-4181-142X-
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