Título:	Prevention and control of Chagas Disease : an overview
Autor(es):	Teixeira, Antonio Raimundo Lima Cruz Gomes, C. Rosa, A. C. Araujo, P. F. Anunciação, C. E. Lacerda, E. Silveira Almeida, A. B. Petrofeza, S.
Assunto:	Chagas, Doença de Trypanosoma cruzi Doenças sexualmente transmissíveis Prevenção
Data de publicação:	2018
Editora:	SCIENCEDOMAIN International
Referência:	TEIXEIRA, A. R. L. et al. Prevention and control of Chagas Disease: an overview. International STD Research & Reviews, v. 7, n.2, Article no.ISRR.42594, 2018. Disponível em: <http://www.sciencedomain.org/abstract/25651>. Anexo em: 02 ago. 2018. doi: 10.9734/ISRR/2018/42594.
Abstract:	Chagas disease is the main cause of heart failure and sudden death in the Western Hemisphere. The literature of the last decades reported on the changing epidemiological profiles of Chagas disease, which now threats the human population in the cities. The exodus of the Latin America people to the Northern Hemisphere explains the growing concern in countries where the transmission of Trypanosoma cruzi was accidental or transferred from a mother to her offspring. Herein, we present the evidence of the possible acquisition of the T. cruzi infection by sex. The staggering demonstration of the transmission of the T. cruzi infections from males and females to naïve mates by intercourse introduces substantial changes in the surveillance of the Chagas disease. Notably, the sexual transmission of the T. cruzi introduces changes in the concepts of medical care, prevention and control; specifically, the risk for the vertical transfer of the parasiteinduced kDNA mutations, underpinning the genetically driven autoimmunity, inheritance, and pathogenesis associated with multifaceted clinical manifestations of Chagas disease with high ratios of morbidity and mortality. In this regard, the endemics require much paradigm research with new approaches and innovation technologies, aiming at its control. For example, the recent knowledge anticipates useful measures for preventing the potential forthcoming pandemic Chagas parasites. A long-lasting multicenter research program is needed for creative, drug discovery for curtailment of Chagas disease. Meanwhile, the prevention shall rely on the education, information, and communication program for health.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	© 2018 Teixeira et al.; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI:	http://dx.doi.org/10.9734/ISRR/2018/42594
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