| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Hiragi, Cássia de Oliveira | - |
| dc.contributor.author | Miranda-Vilela, Ana Luisa | - |
| dc.contributor.author | Rocha, Dulce Maria Sucena | - |
| dc.contributor.author | Oliveira, Silviene Fabiana de | - |
| dc.contributor.author | Hatagima, Ana | - |
| dc.contributor.author | Guimarães, Maria de Nazaré Klautau | - |
| dc.date.accessioned | 2018-05-14T14:08:15Z | - |
| dc.date.available | 2018-05-14T14:08:15Z | - |
| dc.date.issued | 2011 | - |
| dc.identifier.citation | HIRAGI, Cássia de Oliveira et al. Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups. Genetics and Molecular Biology, São Paulo, v. 34, n. 1, p. 11-18, 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100003&lng=en&nrm=iso>. Acesso em 25 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572010005000102. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/31850 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Sociedade Brasileira de Genética | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Antioxidantes | pt_BR |
| dc.subject.keyword | Polimorfismo (Genética) | pt_BR |
| dc.subject.keyword | Genética da população humana | pt_BR |
| dc.subject.keyword | Farmacogenética | pt_BR |
| dc.rights.license | Genetics and Molecular Biology - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (CC BY NC). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100003&lng=en&nrm=iso. Acesso em: 25 out. 2017. | pt_BR |
| dc.identifier.doi | http://dx.doi.org/10.1590/S1415-47572010005000102 | pt_BR |
| dc.description.abstract1 | Antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX1) reduce the oxidation rates in the organism. Gluthatione S-transferases (GSTs) play a vital role in phase 2 of biotransformation of many substances. Variation in the expression of these enzymes suggests individual differences for the degree of antioxidant protection and geographical differences in the distribution of these variants. We described the distribution frequency of CAT (21A/T), SOD2 (Ala9Val), GPX1 (Pro198Leu), GSTM1 and GSTT1 polymorphisms in three Brazilian population groups: Kayabi Amerindians (n = 60), Kalunga Afro-descendants (n = 72), and an urban mixed population from Federal District (n = 162). Frequencies of the variants observed in Kalunga (18% to 58%) and Federal District (33% to 63%) were similar to those observed in Euro and Afro-descendants, while in Kayabi (3% to 68%), depending on the marker, frequencies were similar to the ones found in different ethnic groups. Except for SOD2 in all population groups studied here, and for GPX1 in Kalunga, the genotypic distributions were in accordance with Hardy-Weinberg Equilibrium. These data can clarify the contribution of different ethnicities in the formation of mixed populations, such as that of Brazil. Moreover, outcomes will be valuable resources for future functional studies and for genetic studies in specific populations. If these studies are designed to comprehensively explore the role of these genetic polymorphisms in the etiology of human diseases they may help to prevent inconsistent genotype-phenotype associations in pharmacogenetic studies. | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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