Título:	Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults
Autor(es):	Paula, Roberta S. Souza, Vinícius C. Machado-Silva, Wilcelly Almeida, Bruno Ratier S. Daros, Andersen C. Gomes, Lucy Ferreira, Aparecido P. Brito, Ciro J. Córdova, Cláudio Moraes, Clayton F. Nóbrega, Otávio T.
Assunto:	Biomarcadores Idosos Infarto
Data de publicação:	Dez-2016
Editora:	Faculdade de Medicina / USP
Referência:	PAULA, Roberta S. et al. Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults. Clinics, São Paulo, v. 71, n. 12, p. 725-732, dez. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200725&lng=en&nrm=iso>. Acesso em: 18 dez. 2017. doi: http://dx.doi.org/10.6061/clinics/2016(12)09.
Abstract:	The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.
Licença:	Clinics - This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322016001200725&lng=en&nrm=iso. Acesso em: 18 dez. 2017.
DOI:	http://dx.doi.org/10.6061/clinics/2016(12)09
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