Título:	Activity of Fabaceae species extracts against fungi and Leishmania : vatacarpan as a novel potent anti-Candida agent
Autor(es):	Santana, Dandara Braga Costa, Raphaella Correia da Araújo, Renata Mendonça Paula, José Elias de Silveira, Edilberto Rocha Braz-Filho, Raimundo Espindola, Laila Salmen
Assunto:	Leishmania Fungos
Data de publicação:	Jul-2015
Editora:	Sociedade Brasileira de Farmacognosia
Referência:	SANTANA, Dandara Braga et al. Activity of Fabaceae species extracts against fungi and Leishmania: vatacarpan as a novel potent anti-Candida agent. Revista Brasileira de Farmacognosia, Curitiba, v. 25, n. 4, p. 401-406, jul./ago. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000400401&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1016/j.bjp.2015.07.012.
Abstract:	Leishmaniasis and fungal infection treatment efficacy is limited by toxicity and ever increasing resistance to available drugs, requiring development of alternative compounds. The richness of Cerrado plant antimicrobial secondary metabolites justifies screening of Fabaceae species extracts: Enterolobium ellipticum Benth., Sclerolobium aureum (Tul.) Baill. and Vatairea macrocarpa(Benth.) Ducke, against Leishmania(Leishmania) amazonensis, yeasts and dermatophytes. Among the 26 extracts tested, more than 50% of the total demonstrated significant antifungal activity in comparison to the drug controls (minimal inhibitory concentration 0.12 to ≤31.25 µg/ml). Six extracts capable of complete parasitic growth inhibition had the inhibitory concentration index for 50% values from 9.23 to 78.65 µg/ml. The results led to the selection of the V. macrocarpa ethyl acetate root bark extract for chemical fractionation. This plant, traditionally referred to as angelim-do-cerrado or maleiteira, is used to treat superficial mycoses in Amazonia. A previously unreported pterocarpan vatacarpan together with the known compound musizin was isolated. Vatacarpan demonstrated a minimal inhibitory concentration value of 0.98 µg/ml against Candida albicans ATCC 10231, and thus comparable or superior to fluconazole and amphotericin B. The results add to literature's information the ability of pterocarpans to act as antimicrobial agents.
Licença:	Revista Brasileira de Farmacognosia - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000400401&lng=en&nrm=iso. Acesso em: 17 abr. 2018.
DOI:	http://dx.doi.org/10.1016/j.bjp.2015.07.012
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