Título:	Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
Autor(es):	Colombo, N. B. R. Rangel, M. P. Silva, Vanessa Martins da Hage, Marcia Gelain, Daniel Pens Barbeiro, Denise Frediani Grisolia, Cesar Koppe Parra, Edwin Roger Parra Capelozzi, Vera Luiza
Assunto:	Pequi Stress oxidativo Pulmões - câncer Biologia molecular
Data de publicação:	Set-2015
Editora:	Associação Brasileira de Divulgação Científica
Referência:	COLOMBO, N. B. R. et al. Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 48, n. 9, p. 852-862, set. 2015. DOI: http://dx.doi.org/10.1590/1414-431x20154467. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900852&lng=en&nrm=iso>. Acesso em: 14 out. 2019. Epub July 21, 2015.
Abstract:	The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8-12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 µL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress.
Licença:	Brazilian Journal of Medical and Biological Research - (CC BY) - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900852&lng=en&nrm=iso. Acesso em: 14 out. 2019.
DOI:	http://dx.doi.org/10.1590/1414-431X20154467
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