Título:	Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus
Autor(es):	Vieira, Michele Juliane Perosa, Sandra Regina Argañaraz, Gustavo Adolfo Silva Junior, José Antônio Cavalheiro, Esper Abrão Naffah-Mazzacoratti, Maria da Graça
Assunto:	Anti-inflamatórios Inflamação Epilepsia
Data de publicação:	2014
Editora:	Faculdade de Medicina / USP
Referência:	VIEIRA, Michele Juliane et al. Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus. Clinics, São Paulo, v. 69, n. 9, p. 621-626, set. 2014. DOI: http://dx.doi.org/10.6061/clinics/2014(09)08. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso. Acesso em: 30 out. 2019.
Abstract:	OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.
Licença:	Clinics - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322014000900621&lng=en&nrm=iso&tlng=en. Acesso em: 30 out. 2019.
DOI:	https://dx.doi.org/10.6061/clinics/2014(09)08
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