Título:	Catalyzed and non-catalyzed synthesis of bioactive monastrol
Autor(es):	Alvim, Haline Gerica de Oliveira Corrêa, José Raimundo Machado, Taynara Rezende Silva, Wender Alves da Neto, Brenno A.
Assunto:	Monastrol Reação de Biginelli Catálise
Data de publicação:	2014
Editora:	Sociedade Brasileira de Química
Referência:	ALVIM, Haline Gerica de Oliveira et al. Catalyzed and non-catalyzed synthesis of bioactive monastrol. Química Nova, São Paulo, v. 37, n. 10, p. 1713-1715, 2014. DOI: http://dx.doi.org/10.5935/0100-4042.20140266. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022&lng=en&nrm=iso&tlng=en. Acesso em: 20 jul. 2020.
Abstract:	The bioactive 3,4-dihydropyrimidin-2(1H)-thione derivative known as Monastrol was synthesized under catalyzed and non-catalyzed conditions through the Biginelli multicomponent reaction under solvent-free conditions. The use of two Lewis acids (FeCl3 and CuCl2) and two Brønsted acids (HCl and CF3COOH) as catalysts improved the reaction yields of the transformation compared with the non-catalyzed reaction. The experiments investigated catalysis and its role, the importance of multicomponent reactions and their green features, and the application of these concepts to the synthesis of a biologically important structure.
Unidade Acadêmica:	Instituto de Química (IQ)
Licença:	Química Nova - (CC BY-NC) - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014001000022&lng=en&nr m=iso&tlng=en. Acesso em: 20 jul. 2020.
DOI:	https://dx.doi.org/10.5935/0100-4042.20140266
Aparece nas coleções:	Artigos publicados em periódicos e afins

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